Cytokines are a class of potent immunoregulatory proteins that are secreted in response to
various stimuli and act locally to regulate many aspects of human physiology and disease …

The tremendous clinical success of checkpoint blockers illustrates the potential of
reestablishing latent immunosurveillance for cancer therapy. Although largely neglected in …

Blockade of immune-checkpoints has emerged as one of the most promising approaches to
improve the durability of anti-tumor responses in cancer patients. However, the fraction of …

Traditional treatment modalities for advanced cancer (radiotherapy, chemotherapy, or
targeted agents) act directly on tumors to inhibit or destroy them. Along with surgery, these …

Immunotherapy has become the central pillar of cancer therapy. Immune checkpoint
inhibitors (ICIs), a major category of tumor immunotherapy, reactivate preexisting anticancer …

Efforts over nearly four decades have focused on ways to use cytokines to manipulate the
host immune response towards cancer cell recognition and eradication. Significant …