Spectroscopic analysis reveals the effect of a single nucleotide bulge on G-quadruplex structures

CY Chan, MI Umar, CK Kwok - Chemical communications, 2019 - pubs.rsc.org
Here we investigate and reveal the effect of bulge position and bulge identity on G-
quadruplexes using label-free spectroscopic techniques. Notably, we report significant …

Specific Binding of Anionic Porphyrin and Phthalocyanine to the G-Quadruplex with a Variety of in Vitro and in Vivo Applications

H Yaku, T Murashima, D Miyoshi, N Sugimoto - Molecules, 2012 - mdpi.com
The G-quadruplex, a four-stranded DNA structure with stacked guanine tetrads (G-quartets),
has recently been attracting attention because of its critical roles in vitro and in vivo. In …

Screening of DNA G-quadruplex stabilizing ligands by nano differential scanning fluorimetry

B Pagano, N Iaccarino, A Di Porzio, A Randazzo… - Analyst, 2019 - pubs.rsc.org
G-quadruplex (G4) nucleic acid structures are involved in a number of different diseases and
their drug-induced stabilization is deemed to be a promising therapeutic approach. Herein is …

Revealing the specific interactions between G-quadruplexes and ligands by surface-enhanced Raman spectroscopy

Y Bao, X Zhang, X Xiang, Y Zhang, X Guo - International Journal of …, 2022 - Elsevier
Abstract G-quadruplexes (G4s) regulate a variety of physiological functions related to
diseases and life elongation. Therefore, G4 binding ligands, such as potential drugs in gene …

Colorimetric and fluorescence detection of G-quadruplex nucleic acids with a coumarin–benzothiazole probe

J Yan, Y Tian, J Tan, Z Huang - Analyst, 2015 - pubs.rsc.org
A colorimetric and red-emitting fluorescent dual probe for G-quadruplexes was devised with
a conjugated coumarin–benzothiazole scaffold. Its significant and distinct changes in both …

Functional evaluation of novel chromon derivative compounds for recognition of G-quadruplex structure

N Neha, P Ranjan, S Kumar, RS Singh… - Journal of Molecular …, 2024 - Elsevier
Currently, G-quadruplex structure targeting strategies are considered as a promising
anticancer approach. The purpose of this research is to expand the options for G-quadruplex …

Correlations between fluorescence emission and base stacks of nucleic acid G-quadruplexes

S Gao, Y Cao, Y Yan, X Xiang, X Guo - RSC advances, 2016 - pubs.rsc.org
The aromatic 5/6 ring overlaps at the interface of 5′-5′ stacked dimers formed by two
parallel G-quadruplexes have been demonstrated to produce a characteristic 385 nm …

Verification of intramolecular hybrid/parallel G-quadruplex structure under physiological conditions using novel cyanine dye H-aggregates: Both in solution and on Au …

Q Yang, JF Xiang, S Yang, Q Li, Q Zhou… - Analytical …, 2010 - ACS Publications
The H-aggregates of a novel cyanine dye, 3, 3′-di (3-sulfopropyl)-4, 5, 4′, 5′-dibenzo-9-
methyl-thiacarbocyanine triethylammonium salt (MTC), have been fabricated to verify …

Circular dichroism of DNA G-quadruplexes: combining modeling and spectroscopy to unravel complex structures

H Gattuso, A Spinello, A Terenzi, X Assfeld… - The Journal of …, 2016 - ACS Publications
We report on the comparison between the computational and experimental determination of
electronic circular dichroism spectra of different guanine quadruplexes obtained from human …

Human telomeric G-quadruplex DNA interactions of N-phenanthroline glycosylamine copper (II) complexes

K Duskova, S Sierra, MS Arias-Pérez, L Gude - Bioorganic & Medicinal …, 2016 - Elsevier
We report in this article the interactions of five N-(1, 10-phenanthrolin-5-yl)-β-
glycopyranosylamine copper (II) complexes with G-quadruplex DNA. Specifically, the …