Introduction: Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized
by the translocation t (9; 22), coding for the chimeric protein BCR-ABL. The development of …

Simple Summary Leukemic stem cells represent a rare subpopulation of leukemic cells,
which not only drive leukemia initiation and progression, but also contribute to drug …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm driven by BCR-
ABL1 oncoprotein, which plays a pivotal role in CML pathology, diagnosis, and treatment as …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder characterized by a
chromosome translocation that generates the BCR-ABL oncogene encoding a constitutively …

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder characterized by
the presence of a fusion oncogene BCR‐ABL, which encodes a protein with constitutive TK …

Chronic myeloid leukemia (CML) is caused by the acquisition of the tyrosine kinase BCR-
ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self …

Tyrosine kinase inhibitor (TKI) therapy for chronic myeloid leukaemia (CML) is the
consummate success story for targeted therapy, yet relapse is a nearly inevitable …

Chronic myeloid leukemia stem cells (CML LSCs) are a rare and quiescent population that
are resistant to tyrosine kinase inhibitors (TKI). When TKI therapy is discontinued in CML …

Abstract Treatment with tyrosine kinase inhibitors (TKIs) results in remission and
prolongation of survival in most chronic myeloid leukemia (CML) patients but fails to …

Chronic myeloid leukemia (CML) is a classical example of stem cell cancer since it arises in
a multipotent hematopoietic stem cell upon the acquisition of the t (9; 22) chromosomal …