Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory

M Mather, D Clewett, M Sakaki… - Behavioral and Brain …, 2016 - cambridge.org
Emotional arousal enhances perception and memory of high-priority information but impairs
processing of other information. Here, we propose that, under arousal, local glutamate levels …

Précis on the cognitive-emotional brain

L Pessoa - Behavioral and Brain Sciences, 2015 - cambridge.org
In The Cognitive-Emotional Brain (Pessoa 2013), I describe the many ways that emotion and
cognition interact and are integrated in the brain. The book summarizes five areas of …

Bridging emotion theory and neurobiology through dynamic systems modeling

MD Lewis - Behavioral and brain sciences, 2005 - cambridge.org
Efforts to bridge emotion theory with neurobiology can be facilitated by dynamic systems
(DS) modeling. DS principles stipulate higher-order wholes emerging from lower-order …

Noradrenergic signaling in infralimbic cortex increases cell excitability and strengthens memory for fear extinction

D Mueller, JT Porter, GJ Quirk - Journal of neuroscience, 2008 - Soc Neuroscience
Emotional arousal strengthens memory. This is most apparent in aversive conditioning, in
which the stress-related neurotransmitter norepinephrine (NE) enhances associations …

Noradrenergic modulation of fear conditioning and extinction

TF Giustino, S Maren - Frontiers in behavioral neuroscience, 2018 - frontiersin.org
The locus coeruleus norepinephrine (LC-NE) system plays a broad role in learning and
memory. Here we begin with an overview of the LC-NE system. We then consider how both …

[PDF][PDF] Beyond brain regions: Network perspective of cognition–emotion interactions

L Pessoa, KA Lindquist, TD Wager… - Behavioral and Brain …, 2012 - researchgate.net
Lindquist et al. provide a convincing case against what they call the locationist account of
emotion. Their quantitative approach elegantly illustrates the shortcomings of this still …

Locus coeruleus activity strengthens prioritized memories under arousal

DV Clewett, R Huang, R Velasco, TH Lee… - Journal of …, 2018 - Soc Neuroscience
Recent models posit that bursts of locus ceruleus (LC) activity amplify neural gain such that
limited attention and encoding resources focus even more on prioritized mental …

Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking

H Hu, E Real, K Takamiya, MG Kang, J Ledoux… - Cell, 2007 - cell.com
Emotion enhances our ability to form vivid memories of even trivial events. Norepinephrine
(NE), a neuromodulator released during emotional arousal, plays a central role in the …

Amygdala inactivation reverses fear's ability to impair divided attention and make time stand still.

WH Meck, CJ MacDonald - Behavioral neuroscience, 2007 - psycnet.apa.org
The cognitive and emotional effects of amygdala or frontal cortex lesions were compared in
rats trained to time both a 50-s visual signal paired with food and an embedded 10-or 20-s …

[HTML][HTML] Fear, anxiety, and the amygdala

P Sah - Neuron, 2017 - cell.com
Lee et al.(2017) show that in the basolateral amygdala (BLA), fear and reward are encoded
by phasic activation of distinct populations of neurons, while anxiety results in persistent …