Tight coordination between transcription and translation is crucial to maintaining the integrity
of gene expression in bacteria, yet how bacteria manage to coordinate these two processes …

In bacteria, the first two steps of gene expression—transcription and translation—are
spatially and temporally coupled. Uncoupling may lead to the arrest of transcription through …

Coupled transcription-translation (CTT) is a hallmark of prokaryotic gene expression. CTT
occurs when ribosomes associate with and initiate translation of mRNAs whose transcription …

In bacteria, transcription and translation take place in the same cellular compartment.
Therefore, a messenger RNA can be translated as it is being transcribed, a process known …

Transcription termination is a dynamic process and is subject to control at a number of
levels. New information about the molecular mechanisms of transcription elongation and …

Background In bacteria, the weak correlations at the genome scale between mRNA and
protein levels suggest that not all mRNAs are translated with the same efficiency. To …

This article will review our current understanding of transcription elongation and termination
in E. coli. We discuss why transcription elongation complexes pause at certain template sites …

The ability to determine full-length nucleotide composition of individual RNA molecules is
essential for understanding the architecture and function of a transcriptome. However …

Transcription in bacteria is controlled by multiple molecular mechanisms that precisely
regulate gene expression. It has been recently shown that initial RNA synthesis by the …

Bacteria lack subcellular compartments and harbor a single RNA polymerase that
synthesizes both structural and protein-coding RNAs, which are cotranscriptionally …