1. The work of the perfused rat heart was acutely increased by raising the aortic pressure in
the Langendorff preparation from 50 to 120mmHg; within 1 min in perfusions with media …

1. Transient and steady-state changes caused by acetate utilization were studied in
perfused rat heart. The transient period occupied 6min and steady-state changes were …

Earlier studies with the perfused rat heart have shown that the rate of glycolysis was
inhibited by the addition of fatt) y acids or ketone bodies to the perfusion medium (l-4). The …

1. In the isolated perfused rat heart, the contractile activity and the oxygen uptake were
varied by altering the aortic perfusion pressure, or by the atrial perfusion technique ('working …

An attempt has been made to determine the mechanisms involved in regulating citrate levels
in the rat heart. Citric acid cycle intermediates have been measured in perfused and …

1. The ability of tricarboxylic acid-cycle metabolites to influence the physiological
performance of the perfused anaerobic rat heart was investigated. Energy expenditure/h …

The effects of increased cardiac work on glycolysis, the citric acid cycle, and oxidation of fatty
acids were studied in isolated rat hearts. Glycolysis was stimulated by increased work in …

Flux through the tricarboxylic acid cycle was calculated from oxygen consumption in hearts
perfused near the physiological work load. Activities of citrate synthase, 2-oxoglutarate …

The tissue levels of the glycolytic intermediates and adenine nucleotides were measured in
perfused rat hearts supplied with 20 mm glucose during the transition from aerobiosis to …

Newsholme & Randle (1961) found that the con-centrations of glucose 6-phosphate and
fructose 6-phosphate were decreased and that of fructose 1, 6-diphosphate was increased …