Management of glioblastoma multiforme remains a challenging problem despite recent
advances in targeted therapies. Timely assessment of therapeutic agents is hindered by the …

Background Early detection of treatment response is important for the management of
patients with malignant brain tumors such as glioblastoma to assure good quality of life in …

Current strategies for treatment and management of gliomas incorporate molecular markers
to individualize patient care. Physiologic imaging including magnetic resonance (MR) and …

Objective Summarize evidence for use of advanced MRI techniques as monitoring
biomarkers in the clinic, and highlight the latest bench-to-bedside developments. Methods …

Purpose Parametric response map (PRM) analysis of functional imaging has been shown to
be an effective tool for early prediction of cancer treatment outcomes and may also be well …

Purpose: Currently, radiologic response of brain tumors is assessed according to the
Macdonald criteria 10 weeks from the start of therapy. There exists a critical need to identify …

Quantitative magnetic resonance imaging (MRI)-based biomarkers, which capture
physiological and functional tumor processes, were evaluated as imaging surrogates of …

Quantitative mapping of hyperperfused and hypercellular regions of glioblastoma has been
proposed to improve definition of tumor regions at risk for local recurrence following …

A major challenge in the diagnosis and treatment of brain tumors is tissue heterogeneity
leading to mixed treatment response. Additionally, they are often difficult or at very high risk …

Studies investigating dynamic susceptibility contrast magnetic resonance imaging-
determined relative cerebral blood volume (rCBV) maps as a metric of treatment response …