A wide spectrum of pathogenic mutations of mitochondrial DNA (mtDNA) has been
demonstrated to cause mitochondrial dysfunction and overproduction of reactive oxygen …

The small mammalian mitochondrial DNA (mtDNA) is very gene dense and encodes factors
critical for oxidative phosphorylation. Mutations of mtDNA cause a variety of human …

Mitochondria play an important role in numerous processes, including energy generation,
regulating ion homeostasis, and cell signaling. Mitochondria are also the main source of …

Mitochondrial dysfunction is observed in both the aging brain, and as a core feature of
several neurodegenerative diseases. A central mechanism mediating this dysfunction is …

Aging is a natural phenomenon characterized by progressive decline in tissue and organ
function leading to increased risk of disease and mortality. Among diverse factors that …

Mitochondria are critical for the energetic demands of virtually every cellular process within
nucleated eukaryotic cells. They harbour multiple copies of their own genome (mtDNA), as …

Mitochondria are independent organelles with their own DNA. As a primary function,
mitochondria produce the energy for the cell through Oxidative Phosphorylation (OXPHOS) …

Mitochondrial DNA (mtDNA) mutations appear to be associated with a wide spectrum of
human disorders and proposed to be a potential contributor of aging. However, in an age …

Various endogenous and environmental factors can cause mitochondrial DNA (mtDNA)
damage. One of the reasons for enhanced mtDNA damage could be its proximity to the …

Mitochondria are intracellular organelles responsible for generating ATP through respiration
and oxidative phosphorylation (OXPHOS), producing reactive oxygen species, and initiating …