In mammalian cells, there is an extensive and continuous exchange of mitochondrial DNA
(mtDNA) and its products between mitochondria. This mitochondrial complementation …

A variety of degenerative diseases have now been shown to be caused by mutations in
mitochondrial genes encoded by the mitochondrial DNA (mtDNA) or the nuclear DNA …

A wide variety of mitochondrial DNA (mtDNA) mutations have recently been identified in
degenerative diseases of the brain, heart, skeletal muscle, kidney and endocrine system …

Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

Aging is an intricate phenomenon characterized by progressive decline in physiological
functions and increase in mortality that is often accompanied by many pathological …

Our electron microscopic study of aging insects and mammals suggests that metazoan
senescence is linked to a gradual process of mitochondrial breakdown (and lipofuscin …

During the last decades, our knowledge about the processes involved in the aging process
has exponentially increased. However, further investigation will be still required to globally …

This review is devoted to the molecular genetics and bioenergetics of human mitochondria
related to the mechanism of aging. Morphological and functional changes of mitochondria …

Mitochondrial dysfunction is central to numerous diseases of oxidative stress. Changes in
mitochondrial DNA (MtDNA) content, often measured as mitochondrial genome to nuclear …

Mitochondria are the most important intracellular source of reactive oxygen species and are
protected against them by enzymatic and nonenzymatic antioxidants. Nevertheless …