Cancer is one of the main causes of death worldwide. Despite the significant development of
methods of cancer healing during the past decades, chemotherapy still remains the main …

Inherent and acquired resistance pathways account for the high rate of failure in cancer
chemotherapy. The mechanisms or pathways mediating resistance may be classified as …

Despite the tremendous advances in cancer treatment, resistance to chemotherapeutic
agents impedes higher success rates and accounts for major relapses in cancer therapy …

Cancer is a disease that claims millions of lives each year across the world. Despite
advancement in technologies and therapeutics for treating the disease, these modes are …

Clinically, cancer drug therapy is still dominated by chemotherapy drugs. Although the
emergence of targeted drugs has greatly improved the survival rate of patients with …

Resistance to chemotherapy and molecularly targeted therapies is a major problem facing
current cancer research. The mechanisms of resistance to'classical'cytotoxic …

The ability of cancer cells to become cross-resistant to structurally and functionally unrelated
anti-cancer drugs is known as multidrug resistance. It has been recognized that multidrug …

For many decades classical anti-tumor therapies included chemotherapy, radiation and
surgery; however, in the last two decades, following the identification of the genomic drivers …

Cancers have the ability to develop resistance to traditional therapies, and the increasing
prevalence of these drug resistant cancers necessitates further research and treatment …

Chemotherapy is one of the important methods to treat cancer, and the emergence of
multidrug resistance (MDR) is one major cause for the failure of cancer chemotherapy …