Predictive value of expression of P53, Bcl‐2 and lung resistance‐related protein for response to chemotherapy in non‐small cell lung cancers

T Harada, S Ogura, K Yamazaki, I Kinoshita… - Cancer …, 2003 - Wiley Online Library
Chemoresistance is a major problem in the chemotherapy of non‐small cell lung cancers
(NSCLCs). Several mechanisms are thought to be involved in drug resistance, including …

[HTML][HTML] Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers

L Zhang, B Ye, Z Chen, ZS Chen - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Chemotherapy is one of the important methods to treat cancer, and the emergence of
multidrug resistance (MDR) is one major cause for the failure of cancer chemotherapy …

Different strategies to overcome multidrug resistance in cancer

M Saraswathy, S Gong - Biotechnology advances, 2013 - Elsevier
The risk of acquisition of resistance to chemotherapy remains a major hurdle in the
management of various types of cancer patients. Several cellular and noncellular …

Mechanisms of drug resistance in cancer chemotherapy

YA Luqmani - Medical principles and practice, 2005 - karger.com
The management of cancer involves procedures, which include surgery, radiotherapy and
chemotherapy. Development of chemoresistance is a persistent problem during the …

Unveiling the mechanisms and challenges of cancer drug resistance

SU Khan, K Fatima, S Aisha, F Malik - Cell Communication and Signaling, 2024 - Springer
Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …

Role of long non‐coding RNA in drug resistance in non‐small cell lung cancer

L Wang, L Ma, F Xu, W Zhai, S Dong, L Yin… - Thoracic …, 2018 - Wiley Online Library
Lung cancer is the leading cause of cancer‐associated death, and non‐small cell lung
cancer (NSCLC) accounts for 85% of all lung cancer cases. Many drugs have been used to …

Molecular mechanisms of drug resistance

DB Longley, PG Johnston - The Journal of Pathology: A Journal …, 2005 - Wiley Online Library
Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …

Failure of immunotherapy—the molecular and immunological origin of immunotherapy resistance in lung cancer

J Błach, K Wojas-Krawczyk, M Nicoś… - International Journal of …, 2021 - mdpi.com
Immune checkpoint inhibitors (ICIs) have a huge impact on clinical treatment results in non-
small cell lung cancer (NSCLC). Blocking antibodies targeting programmed cell death …

Circumventing cancer drug resistance in the era of personalized medicine

LA Garraway, PA Jänne - Cancer discovery, 2012 - AACR
All successful cancer therapies are limited by the development of drug resistance. The
increase in the understanding of the molecular and biochemical bases of drug efficacy has …

[HTML][HTML] Cytokines in cancer drug resistance: Cues to new therapeutic strategies

VS Jones, RY Huang, LP Chen, ZS Chen, L Fu… - … et Biophysica Acta (BBA …, 2016 - Elsevier
The development of oncoprotein-targeted anticancer drugs is an invaluable weapon in the
war against cancer. However, cancers do not give up without a fight. They may develop …