[HTML][HTML] Apolipoprotein B-containing lipoprotein assembly in microsomal triglyceride transfer protein-deficient McA-RH7777 cells

Y Liu, M Manchekar, Z Sun, PE Richardson… - Journal of lipid …, 2010 - ASBMB
Microsomal triglyceride transfer protein (MTP) is required for the assembly and secretion of
apolipoprotein (apo) B-containing lipoproteins. Previously, we demonstrated that the N …

[HTML][HTML] Microsomal triglyceride transfer protein activity is not required for the initiation of apolipoprotein B-containing lipoprotein assembly in McA-RH7777 cells

N Dashti, M Manchekar, Y Liu, Z Sun… - Journal of Biological …, 2007 - ASBMB
We previously demonstrated that the N-terminal 1000 amino acid residues of human
apolipoprotein (apo) B (designated apoB: 1000) are competent to fold into a three-sided …

Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly

DA Gordon, H Jamil - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2000 - Elsevier
The microsomal triglyceride transfer protein (MTP) is necessary for the proper assembly of
the apolipoprotein B containing lipoproteins, very low density lipoprotein and chylomicrons …

[HTML][HTML] The microsomal triglyceride transfer protein facilitates assembly and secretion of apolipoprotein B-containing lipoproteins and decreases cotranslational …

S Wang, RS McLeod, DA Gordon, Z Yao - Journal of Biological Chemistry, 1996 - ASBMB
We studied the role of microsomal triglyceride transfer protein (MTP) in the synthesis,
secretion, and cotranslational degradation of apolipoprotein (apo) B using nonhepatic COS …

[HTML][HTML] Generation of hepatoma cell lines deficient in microsomal triglyceride transfer protein

N Anaganti, A Chattopadhyay, JT Poirier… - Journal of Lipid …, 2022 - ASBMB
The microsomal triglyceride transfer protein (MTP) is essential for the secretion of
apolipoprotein B (apoB) 48-and apoB100-containing lipoproteins in the intestine and liver …

[HTML][HTML] Identification of a novel isoform of microsomal triglyceride transfer protein

PJ Mohler, MY Zhu, AM Blade, AJL Ham… - Journal of Biological …, 2007 - ASBMB
Microsomal triglyceride transfer protein (MTP) has been studied extensively, primarily
because of its role in the assembly of very low density lipoproteins by the liver and …

[HTML][HTML] Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in …

DA Gordon, H Jamil, RE Gregg, SO Olofsson… - Journal of Biological …, 1996 - ASBMB
The microsomal triglyceride transfer protein (MTP) is required for assembly and secretion of
the lipoproteins containing apolipoprotein B (apoB): very low density lipoproteins and …

[HTML][HTML] The activity of microsomal triglyceride transfer protein is essential for accumulation of triglyceride within microsomes in McA-RH7777 cells: a unified model for …

Y Wang, K Tran, Z Yao - Journal of Biological Chemistry, 1999 - ASBMB
Previously, based on distinct requirement of microsomal triglyceride transfer protein (MTP)
and kinetics of triglyceride (TG) utilization, we concluded that assembly of very low density …

[HTML][HTML] Evidence that microsomal triglyceride transfer protein is limiting in the production of apolipoprotein B-containing lipoproteins in hepatic cells

H Jamil, CH Chu, JK Dickson, Y Chen, M Yan… - Journal of lipid …, 1998 - ASBMB
The microsomal triglyceride transfer protein (MTP) is a heterodimeric lipid transfer protein
that is required for the assembly and secretion of apolipoprotein B (apoB)-containing …

[HTML][HTML] Chinese hamster ovary cells require the coexpression of microsomal triglyceride transfer protein and cholesterol 7α-hydroxylase for the assembly and …

JF Fleming, GM Spitsen, TY Hui, L Olivier, EZ Du… - Journal of Biological …, 1999 - ASBMB
Due to the absence of microsomal triglyceride transfer protein (MTP), Chinese hamster
ovary (CHO) cells lack the ability to translocate apoB into the lumen of the endoplasmic …