To understand features of human obesity and type 2 diabetes mellitus (T2D) that can be
recapitulated in the mouse, we compared C57BL/6J mice fed a Western‐style diet (WD) to …

Metabolic syndrome and T2D produce significant health and economic issues. Many
available animal models have monogenic leptin pathway mutations that are absent in the …

Obese, diabetic C57BL/Ks db/db mice that lack the long-form leptin receptor exhibit no
decrease in body weight or food intake when treated with leptin. Here we compared …

OBJECTIVE To identify metabolic derangements contributing to diabetes susceptibility in the
leptin receptor–deficient obese C57BLKS/J-db/db (BKS-db) mouse strain. RESEARCH …

Among the most widely used animal models in obesity-induced type 2 diabetes mellitus
(T2DM) research are the congenital leptin-and leptin receptor-deficient rodent models …

We have previously shown that C57BL/6J (B6) mice develop severe obesity and diabetes if
weaned onto high-fat diets, whereas A/J mice tend to be obesity and diabetes-resistant. The …

β-Cell failure is a hallmark of type 2 diabetes. Among several cellular biological mechanisms
of cellular dysfunction, we and others have recently proposed that dedifferentiation of β-cells …

The Zucker fatty (ZF) rat harboring a missense mutation (fatty, fa) in the leptin receptor gene
(Lepr) develops obesity without diabetes; Zucker diabetic fatty (ZDF) rats derived from the ZF …

The prevalence of type 2 diabetes (T2DM) is increasing, creating a need for T2DM animal
models for the study of disease pathogenesis, prevention, and treatment. The purpose of this …

The β-cell is a highly specialized cell with a unique differentiation that optimizes glucose-
induced insulin secretion (GIIS). Here, we evaluated changes in gene expression that …