As a global health problem, sickle cell anemia affects many world populations. Since its
initial description in the United States almost a century ago, scientists and medical …

The first reported case of sickle cell anemia in America was published in 1910 by James
Herrick. 1 Forty-seven years later the A→ T mutation in the β-globin gene was discovered, to …

The discovery of the molecular basis of sickle cell disease was an important landmark in
molecular medicine. The modern tools of molecular and cellular biology have refined our …

Although sickle cell anemia was the first molecular disease to be identified, its complex and
fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin …

Although sickle cell anemia was the first molecular disease to be identified, its complex and
fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin …

For years, Geraldine Haywood didn't believe she had sickle cell anemia. Even though she
was homozygous for the beta S gene, which means she had inherited a sickle cell gene …

Sickle cell disease (SCD) is a global public health disorder that affects millions of people
across the globe. It is a monogenic disorder caused by an A-to-T point mutation in the β …

The first clinical description of sickle cell anemia was published in 1910 by Herri~ k?~ who
reported some of the clinical and hematologic manifestations of the disorder in a 20-year-old …

Sickle cell disease (SCD) was the first “molecular” disease, but protean clinical
manifestations belie simple molecular origins. The abnormal biophysical characteristics of …

Although more is known about sickle cell disease than about any other inherited disease, no
cure for it exists. In America alone, about one in 375 who are of African ancestry is born with …