[HTML][HTML] NR0B1 suppresses ferroptosis through upregulation of NRF2/c-JUN-CBS signaling pathway in lung cancer cells

XY Zhang, H Zhang, SJ Hu, SY Liao… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Ferroptosis has demonstrated significant potential in treating radiochemotherapy-resistant
cancers, but its efficacy can be affected by recently discovered ferroptosis suppressors. In …

Targeting Nrf2 for ferroptosis-based therapy: Implications for overcoming ferroptosis evasion and therapy resistance in cancer

J Lee, JL Roh - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2023 - Elsevier
Ferroptosis is a newly discovered form of programmed cell death caused by redox-active
iron-mediated lipid peroxidation. Ferroptosis exhibits a unique morphological phenotype …

[HTML][HTML] High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation

I De Souza, LKS Monteiro, CB Guedes, MM Silva… - Cell Death & …, 2022 - nature.com
Glioblastoma patients have a poor prognosis mainly due to temozolomide (TMZ) resistance.
NRF2 is an important transcript factor involved in chemotherapy resistance due to its …

Nrf2 suppresses erastin-induced ferroptosis through activating system Xc (-) in ovarian cancer

Y Li, R Yin, M Liang, C Chen - Molecular & Cellular Toxicology, 2024 - Springer
Background Ovarian cancer (OV) is a gynecologic tumor with high mortality due to its drug
resistance. In most cases, simple standard care is not satisfactory. Ferroptosis as a non …

[HTML][HTML] Inhibition of PKA/CREB1 pathway confers sensitivity to ferroptosis in non-small cell lung cancer

G Shan, G Bi, G Zhao, J Liang, Y Bian, H Zhang… - Respiratory …, 2023 - Springer
Ferroptosis is a type of regulated cell death characterized by iron accumulation and lipid
peroxidation. The molecular mechanisms underlying ferroptosis regulation in non-small cell …

[HTML][HTML] Targeting ferroptosis pathway to combat therapy resistance and metastasis of cancer

X Liu, Y Zhang, X Wu, F Xu, H Ma, M Wu… - Frontiers in …, 2022 - frontiersin.org
Ferroptosis is an iron-dependent regulated form of cell death caused by excessive lipid
peroxidation. This form of cell death differed from known forms of cell death in morphological …

Clobetasol propionate, a Nrf-2 inhibitor, sensitizes human lung cancer cells to radiation-induced killing via mitochondrial ROS-dependent ferroptosis

A Rai, RS Patwardhan, S Jayakumar… - Acta Pharmacologica …, 2024 - nature.com
Combining radiotherapy with Nrf-2 inhibitor holds promise as a potential therapeutic strategy
for radioresistant lung cancer. Here, the radiosensitizing efficacy of a synthetic glucocorticoid …

Lysionotin induces ferroptosis to suppress development of colorectal cancer via promoting Nrf2 degradation

Z Gao, J Jiang, L Hou, F Ji - Oxidative Medicine and Cellular …, 2022 - Wiley Online Library
Extensive use of substances derived from natural sources has been documented in the
treatment of colorectal cancer (CRC). Lysionotin (Lys) is a flavonoid present in the flowers …

Cisplatin synergizes with PRLX93936 to induce ferroptosis in non-small cell lung cancer cells

Z Liang, W Zhao, X Li, L Wang, L Meng, R Yu - … and Biophysical Research …, 2021 - Elsevier
Ferroptosis is a newly identified type of regulated cell death that is affected by lipid
peroxidation and reactive oxygen species (ROS). In the current study, we showed that …

Dysregulation of ferroptosis may involve in the development of non‐small‐cell lung cancer in Xuanwei area

G Li, J Yang, G Zhao, Z Shen, K Yang… - Journal of Cellular …, 2021 - Wiley Online Library
Abstract The Xuanwei area of Yunnan Province, China, is one of the regions suffering from
the highest occurrence and mortality rate of lung cancer in the world. Local residents tend to …