Background Several neurotransmitters are expressed in the neurons of the trigeminal
ganglion. One such signalling molecule is the pituitary adenylate cyclase-activating peptide …

The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-
activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both …

Migraine is the seventh most disabling disorder globally, with prevalence of 11.7%
worldwide. One of the prevailing mechanisms is the activation of the trigeminovascular …

Neurotransmitter and headache target localization in the trigeminal ganglia (TG) might
increase the understanding of sites of action, and mechanisms related to headache therapy …

The neuropeptide pituitary adenylate cyclase‐activating polypeptide (PACAP) has been
implicated in a wide range of functions including vasodilatation, neuroprotection …

The origin of migraine pain has not yet been clarified, but accumulating data point to
neuropeptides present in the perivascular space of cranial vessels as important mediators of …

Background Pituitary adenylate cyclase-activating polypeptide (PACAP) is a multipotent
neuropeptide widely distributed in the trigeminovascular system (TVS) and higher brain …

Background: Migraine is a common type of primary headache with disabling brain
dysfunction. It has been found that pituitary adenylate cyclase activating polypeptide …

Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors are widely
distributed at different levels of the pain-processing pathway. Its action at the peripheral …

Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical
complex and can trigger migraine. PACAP levels were measured using a sensitive …