Mammalian cells respond to extracellular stimuli by activating signaling cascades that are
mediated by members of the MAP kinase family. MAP kinases act by phosphorylating …

The c-Jun N-terminal kinase (JNK) group of mitogen-activated protein kinases (MAP
kinases) is activated by exposure of cells to environmental stress and by the treatment of …

The transcriptional activity of c-Jun is augmented through phosphorylation at two sites by a c-
Jun amino-terminal kinase (JNK). All cells express two distinct JNK activities, 46 and 55 kD …

Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members function in a cell context-specific and cell type-specific manner to integrate signals …

Cells respond to changes in the physical and chemical properties of the environment. These
changes include alterations in the amount of nutrients, growth factors, cytokines, and …

JNK/SAPKs are identified as new members of the MAPK family; they phosphorylate c-Jun
protein in response to several cellular stimuli including ultraviolet irradiation, TNF and …

c-Jun NH 2-terminal protein kinase (JNK), a distant member of the mitogen-activated protein
(MAP) kinase family, regulates gene expression in response to various extracellular stimuli …

Background Members of the MAP kinase superfamily play important roles in a wide variety
of signal transduction pathways, and several members have been identified. However, the …

The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is
activated by phosphorylation on Thr and Tyr. Here we report the molecular cloning of a new …

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