Background Accumulating evidence has shown that the NOD-like receptor protein 3
(NLRP3) inflammasome plays a crucial role in the inflammatory cascades involved in the …

Acute pancreatitis (AP) is an inflammatory disease, and NLRP3 inflammasome activation is
involved in the pathogenesis of AP. Previous research showed that inhibition of NLRP3 …

The discovery of inflammasomes has enriched our knowledge in the pathogenesis of
multiple inflammatory diseases. The NLR pyrin domain-containing protein 3 (NLRP3) has …

Increasing evidence has demonstrated that reactive oxygen species (ROS) induces
oxidative stress and plays a crucial role in the pathogenesis of acute pancreatitis (AP) …

Background & Aims Pancreatitis starts with primarily sterile local inflammation that induces
systemic inflammatory response syndrome, followed by compensatory anti-inflammatory …

NLRP3 inflammasome activation plays an important role in the development of pancreatic
fibrosis. However, it is unclear whether the activation of the NLRP3 inflammasome is directly …

NLRP3 inflammasome is a multiprotein complex expressed in a variety of cells to stimulate
the production of inflammatory factors. Activation of NLRP3 inflammasome depends on a …

BACKGROUND & AIMS: Acute pancreatitis is characterized by early activation of
intracellular proteases followed by acinar cell death and inflammation. Activation of damage …

Acute pancreatitis (AP), while most often a mild and self-limiting inflammatory disease,
worsens to a characteristically necrotic severe acute pancreatitis (SAP) in about 20% of …

The rapid production and release of a large number of inflammatory cytokines can cause
excessive local and systemic inflammation in severe acute pancreatitis (SAP) and multiple …