Effective reuse of a quantitative mathematical model requires not just access to curated
versions of the model equations, but also an understanding of the functional capabilities of …

The modelling of the electrophysiology of cardiac cells is one of the most mature areas of
systems biology. This extended concentration of research effort brings with it new …

Computational modeling of cardiac cellular electrophysiology has a long history, and many
models are now available for different species, cell types, and experimental preparations …

The traditional cardiac model-building paradigm involves constructing a composite model
using data collected from many cells. Equations are derived for each relevant cellular …

The use of mathematical models to study cardiac electrophysiology has a long history, and
numerous cellular scale models are now available, covering a range of species and cell …

A major challenge in computational biology is constraining free parameters in mathematical
models. Adjusting a parameter to make a given model output more realistic sometimes has …

Chaste is an open-source C++ library for computational biology that has well-developed
cardiac electrophysiology tissue simulation support. In this paper, we introduce the features …

In recent years there has been much development of the fundamental ideas underlying
mathematical model curation in regard to models of biology. While much has been achieved …

Biophysically detailed cardiac cell models are based upon stiff ordinary differential
equations describing ionic channels and intracellular dynamics aiming at reproducing …

Biophysically detailed cardiac cell models reconstruct the action potential and calcium
dynamics of cardiac myocytes. They aim to capture the biophysics of current flow through ion …