Collagen fiber centerline tracking in fibrotic tissue via deep neural networks with variational autoencoder-based synthetic training data generation
The role of fibrillar collagen in the tissue microenvironment is critical in disease contexts
ranging from cancers to chronic inflammations, as evidenced by many studies. Quantifying …
ranging from cancers to chronic inflammations, as evidenced by many studies. Quantifying …
Quantifying fibrillar collagen organization with curvelet transform-based tools
Y Liu, KW Eliceiri - JoVE (Journal of Visualized Experiments), 2020 - jove.com
Fibrillar collagens are prominent extracellular matrix (ECM) components, and their topology
changes have been shown to be associated with the progression of a wide range of …
changes have been shown to be associated with the progression of a wide range of …
Non-disruptive collagen characterization in clinical histopathology using cross-modality image synthesis
The importance of fibrillar collagen topology and organization in disease progression and
prognostication in different types of cancer has been characterized extensively in many …
prognostication in different types of cancer has been characterized extensively in many …
Tumor collagen framework from bright-field histology images predicts overall survival of breast carcinoma patients
Within the tumor microenvironment, specifically aligned collagen has been shown to
stimulate tumor progression by directing the migration of metastatic cells along its structural …
stimulate tumor progression by directing the migration of metastatic cells along its structural …
Methods for quantifying fibrillar collagen alignment
Y Liu, A Keikhosravi, GS Mehta, CR Drifka… - Fibrosis: methods and …, 2017 - Springer
Recent evidence has implicated collagen, particularly fibrillar collagen, in a number of
diseases ranging from osteogenesis imperfecta and asthma to breast and ovarian cancer. A …
diseases ranging from osteogenesis imperfecta and asthma to breast and ovarian cancer. A …
Fibrillar collagen quantification with curvelet transform based computational methods
Y Liu, A Keikhosravi, CA Pehlke… - … in bioengineering and …, 2020 - frontiersin.org
Quantification of fibrillar collagen organization has given new insight into the possible role of
collagen topology in many diseases and has also identified candidate image-based bio …
collagen topology in many diseases and has also identified candidate image-based bio …
Navigating the collagen jungle: the biomedical potential of fiber organization in cancer
JN Ouellette, CR Drifka, KB Pointer, Y Liu… - Bioengineering, 2021 - mdpi.com
Recent research has highlighted the importance of key tumor microenvironment features,
notably the collagen-rich extracellular matrix (ECM) in characterizing tumor invasion and …
notably the collagen-rich extracellular matrix (ECM) in characterizing tumor invasion and …
Quantitative classification of 3D collagen fiber organization from volumetric images
Collagen fibers in biological tissues have a complex 3D organization containing rich
information linked to tissue mechanical properties and are affected by mutations that lead to …
information linked to tissue mechanical properties and are affected by mutations that lead to …
Rapid quantification of 3D collagen fiber alignment and fiber intersection correlations with high sensitivity
Metastatic cancers aggressively reorganize collagen in their microenvironment. For
example, radially orientated collagen fibers have been observed surrounding tumor cell …
example, radially orientated collagen fibers have been observed surrounding tumor cell …
Type I Collagen D-Spacing in Fibril Bundles of Dermis, Tendon, and Bone: Bridging between Nano- and Micro-Level Tissue Hierarchy
M Fang, EL Goldstein, AS Turner, CM Les, BG Orr… - ACS …, 2012 - ACS Publications
Fibrillar collagens in connective tissues are organized into complex and diverse hierarchical
networks. In dermis, bone, and tendon, one common phenomenon at the micrometer scale …
networks. In dermis, bone, and tendon, one common phenomenon at the micrometer scale …