The role of cyclooxygenase-2 (COX-2) in colorectal tumorigenesis in mice was studied by
Oshima et al. to determine the effects of COX-2 gene knockouts and a new COX-2 inhibitor …

Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H
2: constitutive COX-1 and inducible COX-2. To assess the role of COX-2 in colorectal …

Mutations of the adenomatous polyposis coli gene (Apc) have been implicated in the
occurrence of sporadic colon cancer. Various Apc knockout strains of mice have been …

Abstract Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers …

Cyclooxygenase (COX), the key regulatory enzyme for prostaglandin synthesis, is
transcribed from two distinct genes. COX-1 is expressed constitutively in most tissues …

Publisher Summary Cyclooxygenase, prostaglandin synthase, is expressed in mammalian
cells as two distinct isosymes that show about 60% amino acid sequence identity. The two …

Abstract Cyclooxygenase‐2 (COX‐2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. A …

Early experiments performed during 1980s and 1990s using carcinogen-induced rat
intestinal tumor models demonstrated the inhibitory effects of non-steroidal anti-inflammatory …

Summary Expression of cyclooxygenase 2 (COX-2) is believed to play an important role in
adenoma formation in murine polyposis models, and inhibition of COX-2 activity may, at …

Abstract Cyclooxygenase-2 (COX-2), a key enzyme of prostanoid biosynthesis, plays an
important role in both hereditary and spontaneous colon cancer. Individuals with ulcerative …