Background & Aims: Interleukin (IL)-21, a T-cell-derived cytokine, is overproduced in
inflammatory bowel diseases (IBD), but its role in the pathogenesis of gut inflammation …

Background We previously demonstrated that in inflammatory bowel disease (IBD) there is
enhanced production of interleukin (IL)-21, a cytokine that activates multiple pathways that …

Background & Aims T-helper (Th) 1 cells play a central role in the pathogenesis of tissue
damage in Crohn's disease (CD). Interleukin (IL)-12/STAT4 signaling promotes Th1 cell …

Background & Aims: Interleukin (IL)-21, a T-cell–derived cytokine, is produced in excess in
inflammatory bowel diseases (IBD). The IL-21 receptor (IL-21R) is expressed by immune …

Background & Aims: Interleukin (IL)-23 supports a distinct lineage of T cells producing IL-17
(Th17) that can mediate chronic inflammation. This study was performed to define the role of …

Background Interleukin-21 (IL-21) is involved in T and NK cell activation and effector
response and promotes Th17 cell differentiation. Here we investigated IL-21 receptor (IL …

Abstract Background Inflammatory bowel diseases (IBDs) such as Crohn's disease and
ulcerative colitis are characterized by recurrent inflammation in the gastrointestinal tract …

Background T helper (TH) 17 cells are believed to play a pivotal role in development of
inflammatory bowel disease, and their contribution to intestinal inflammation has been …

In both Crohn's disease (CD) and ulcerative colitis, the pathologic process is almost certainly
driven by an aberrant local immune response directed against normal components of the …

Mice deficient in the IL-10 pathway are the most widely used models of intestinal
immunopathology. IL-17A is strongly implicated in gut disease in mice and humans, but …