Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

Y Lee, E Puumala, N Robbins, LE Cowen - Chemical reviews, 2020 - ACS Publications
Fungal infections are a major contributor to infectious disease-related deaths across the
globe. Candida species are among the most common causes of invasive mycotic disease …

Molecular mechanisms governing antifungal drug resistance

Y Lee, N Robbins, LE Cowen - npj Antimicrobials and Resistance, 2023 - nature.com
Fungal pathogens are a severe public health problem. The leading causative agents of
systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus …

Molecular evolution of antifungal drug resistance

N Robbins, T Caplan, LE Cowen - Annual review of …, 2017 - annualreviews.org
The fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus
fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The …

Emerging threats in antifungal-resistant fungal pathogens

D Sanglard - Frontiers in medicine, 2016 - frontiersin.org
The use of antifungal drugs in the therapy of fungal diseases can lead to the development of
antifungal resistance. Resistance has been described for virtually all antifungal agents in …

Elucidating drug resistance in human fungal pathogens

JL Xie, EJ Polvi, T Shekhar-Guturja… - Future microbiology, 2014 - Taylor & Francis
Fungal pathogens cause life-threatening infections in immunocompetent and
immunocompromised individuals. Millions of people die each year due to fungal infections …

Mechanisms of antifungal drug resistance

LE Cowen, D Sanglard… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Antifungal therapy is a central component of patient management for acute and chronic
mycoses. Yet, treatment choices are restricted because of the sparse number of antifungal …

Candida Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents

C Spampinato, D Leonardi - BioMed research international, 2013 - Wiley Online Library
The genus Candida includes about 200 different species, but only a few species are human
opportunistic pathogens and cause infections when the host becomes debilitated or …

Emerging virulence, drug resistance and future anti-fungal drugs for Candida pathogens

V Srivastava, RK Singla… - Current topics in medicinal …, 2018 - ingentaconnect.com
Increased incidences of Candida infection have augmented morbidity and mortality in
human population, particularly among severely immunocompromised patients and those …

Recent insights into the mechanisms of antifungal resistance

KS Barker, PD Rogers - Current infectious disease reports, 2006 - Springer
The incidence of fungal infections has increased in recent years, particularly among
immunocompromised individuals. Treatment of invasive fungal infections has been …

Antifungal drug resistance among Candida species: mechanisms and clinical impact

M Sanguinetti, B Posteraro, C Lass‐Flörl - Mycoses, 2015 - Wiley Online Library
The epidemiology of Candida infections has changed in recent years. Although Candida
albicans is still the main cause of invasive candidiasis in most clinical settings, a substantial …