Large bowel cancer is not only the third most frequent cancer in the world but is one of the
most common human malignancies in Western countries, including North America. In recent …

During recent years, multidisciplinary studies in epidemiology and molecular biology, as
well as preclinical studies, have contributed much to our understanding of the etiology of …

Colorectal cancer (CRC) accounts for nearly 12% of newly diagnosed cancers in the United
States and is the second leading cause of cancer deaths (1, 2). Multidisciplinary research in …

Colorectal cancer is the third most incident cancer in the United States and is second only to
lung cancer as a cause of cancer-related mortality. Colorectal cancer develops through a …

Large bowel cancer is one of the most common human malignancies in western countries,
including North America. Several epidemiological studies have detected decreases in the …

Prevention of human diseases has become a major focus of biomedical investigators
around the world. Our current screening and treatment regimens for colorectal cancer are …

There is mounting evidence from studies on experimental cancer in rodents, interventional
studies in patients with familial adenomatous polyposis, and some, but not all, epidemiologic …

Increasing evidence suggests that aspirin and other nonsteroidal anti-inflammatory drugs
(NSAIDs) reduce the risk of colorectal cancer. This observation is supported by results from …

OBJECTIVE: To discuss the role of nonsteroidal antiinflammatory drugs (NSAIDs) in the
chemoprevention of colorectal cancer. DATA SOURCES: A MEDLINE search (1966–May …

Risk factors for colorectal cancer have been identified, and significant advances have been
made in understanding the process of colorectal carcinogenesis. The transition from normal …