Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase?
DS Alberts, L Hixson, D Ahnen, C Bogert… - Journal of Cellular …, 1995 - Wiley Online Library
Nonsteroidal antiinflammatory drugs (NSAIDs) have considerable potential as
chemopreventive agents for colorectal cancer. Recent case‐control drug surveillance and …
chemopreventive agents for colorectal cancer. Recent case‐control drug surveillance and …
Nonsteroidal anti-inflammatory drugs, eicosanoids, and colorectal cancer prevention
RN DuBois, FM Giardiello… - Gastroenterology …, 1996 - gastro.theclinics.com
Colorectal cancer is the second leading cause of death from cancer in the United States.
Differences in dietary habits and lifestyles among populations in different geographic …
Differences in dietary habits and lifestyles among populations in different geographic …
Cyclooxygenase-2: a novel target for cancer chemotherapy?
W Dempke, C Rie, A Grothey, HJ Schmoll - Journal of cancer research and …, 2001 - Springer
Epidemiologic studies have documented a 40–50% reduction in incidence of colorectal
cancer in individuals taking nonsteroidal antiinflammatory drugs (NSAIDs). Since NSAIDs …
cancer in individuals taking nonsteroidal antiinflammatory drugs (NSAIDs). Since NSAIDs …
Coxibs: pharmacology, toxicity and efficacy in cancer clinical trials
LA Garcia Rodriguez, L Cea-Soriano… - … for Chemoprevention of …, 2013 - Springer
This chapter briefly summarizes the current knowledge about the role of nonsteroidal anti-
inflammatory drugs (NSAIDs), specially focusing on those selective for cyclooxygenase …
inflammatory drugs (NSAIDs), specially focusing on those selective for cyclooxygenase …
Cyclooxygenase-2 inhibitors in colorectal cancer
J Stoehlmacher, HJ Lenz - Seminars in oncology, 2003 - Elsevier
Cyclooxygenase (COX) enzyme-dependent arachidonic acid metabolites occupy key
positions in important physiologic processes such as immunity, reproduction, and vascular …
positions in important physiologic processes such as immunity, reproduction, and vascular …
Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual …
G Lal, C Ash, K Hay, M Redston, E Kwong, B Hancock… - Cancer Research, 2001 - AACR
Epidemiological studies suggest that nonsteroidal anti-inflammatory agents decrease the
risk of colorectal cancer. This is believed to be mediated, at least in part, by inhibition of …
risk of colorectal cancer. This is believed to be mediated, at least in part, by inhibition of …
Nonsteroidal antiinflammatory drugs and cyclooxygenase inhibition in the gastrointestinal tract: a trip from peptic ulcer to colon cancer
A Lanas - The American journal of the medical sciences, 2009 - Elsevier
Aspirin was commercialized more than a 100 years ago. Today, this compound is still widely
prescribed, and new mechanisms of action and indications are being tested. Inhibition of …
prescribed, and new mechanisms of action and indications are being tested. Inhibition of …
Cyclooxygenase-2 (COX-2) in carcinogenesis and selective COX-2 inhibitors for chemoprevention in gastrointestinal cancers
T Fujimura, T Ohta, K Oyama, T Miyashita… - Journal of gastrointestinal …, 2007 - Springer
Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to have a
property to inhibit tumor development in some cancers while it shows various side effects …
property to inhibit tumor development in some cancers while it shows various side effects …
The role of nonsteroidal anti-inflammatory drugs in colorectal cancer prevention
FM Giardiello, GJA Offerhaus, RN DuBois - European Journal of Cancer, 1995 - Elsevier
Colorectal cancer is the second leading cause of cancer death in the USA Recent research
suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in the prevention …
suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in the prevention …
Celecoxib Prevents Tumor Growth in Vivo without Toxicity to Normal Gut: Lack of Correlation between in Vitro and in Vivo Models
CS Williams, AJM Watson, H Sheng, R Helou, J Shao… - Cancer research, 2000 - AACR
Nonsteroidal anti-inflammatory drugs have potential for use in the prevention and/or
treatment of colorectal cancer. We have studied the cytotoxic effect of a specific COX-2 …
treatment of colorectal cancer. We have studied the cytotoxic effect of a specific COX-2 …