Cancer stem cells (CSCs), which have a close connection with tumor microenvironment,
play a pivotal role in tumorigenesis, tumor progression, and metastasis. The inflammatory …

We identify novel mechanisms whereby chemoresistance enables cancer stem cells to
create pro-inflammatory tumor microenvironments. Chemoresistant cancer stem cells …

The relationship between inflammation and cancer has attracted attention for a long time.
The inflammatory tumor microenvironment consists of inflammatory cells, chemokines …

There is substantial evidence that many human cancers are driven by a subpopulation of
cells that display stem cell properties. These cancer stem cells (CSC) may also contribute to …

Malignant tumors pose a great challenge to human health, which has led to many studies
increasingly elucidating the tumorigenic process. Cancer Stem Cells (CSCs) have profound …

Purpose Cancer cells, despite stemming from the own cells of their host, usually elicit an
immune response. This response usually enables elimination of cancer at its earliest stages …

Since the" seed and soil" hypothesis was proposed, the biological functions of the tumor
microenvironment (TME), especially its stromal components, have received increasing …

Tumor behavior is not entirely determined by tumor cells. Studies have demonstrated that a
variety of non-tumor cells in the tumor microenvironment affect tumor behavior; thus, a new …

Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …

Recent studies have revealed that tumor-associated macrophages are the most abundant
stromal cells in the tumor microenvironment and play an important role in tumor initiation …