The idea that a common pathology underlies various neurodegenerative diseases and
dementias has attracted considerable attention in the basic and medical sciences …

Abstract PQBP1 (polyglutamine binding protein-1) is the earliest identified molecule among
the group of disease-related intrinsically disordered/denatured proteins. PQBP1 interacts …

Mutations of PQBP‐1 (polyglutamine binding protein‐1) have been shown recently to cause
human mental retardation accompanied by microcephaly at a high frequency. As a first step …

We report two discordant clinical and imaging features in four male patients from two
unrelated families of Egyptian descent with hemizygous pathogenic variants in PQBP1. The …

A body of experimental evidence indicates that transcription and/or mRNA processing
factors interacting with the polyglutamine disease gene products play crucial roles in the …

Frame shift mutations of the polyglutamine binding protein-1 (PQBP1) gene lead to total or
partial truncation of the C-terminal domain (CTD) and cause mental retardation in human …

A novel gene, designated PQBP-1, which encodes a 265 residue protein that binds to the
polyglutamine tract of the brain-specific transcription factor Brn-2, was identified. PQBP-1 …

Polyglutamine (Q) tract binding protein-1 (PQBP-1) was isolated on the basis of its
interaction with polyglutamine tracts and localizes predominantly to the nucleus where it …

PQBP-1 was identified as a binding protein to the polyglutamine tract present in various
transcription-related factors and causative genes for neurodegenerative disorders. This …

Protein misfolding and aggregation in the brain have been recognized to be crucial in the
pathogenesis of various neurodegenerative diseases, including Alzheimer's, Parkinson's …