Activated PI3 kinase delta syndrome (APDS) is a primary immunodeficiency caused by
dominant mutations that increase activity of phosphoinositide-3-kinase δ (PI3Kδ). APDS can …

Phosphoinositide-3-kinase δ (PI3Kδ) is found in immune cells and is part of the
PI3K/AKT/mTOR/S6K signalling pathway essential to cell survival, growth and differentiation …

Abstract Activated phosphatidylinositol 3-kinase-δ (PI3K-δ) syndrome (APDS) is a rare
primary combined immunodeficiency caused by either dominant gain-of-function mutations …

Activated phosphoinositide 3-kinase delta syndrome (APDS) is a novel primary
immunodeficiency (PID) caused by heterozygous gain of function mutations in PI3Kδ …

Activated PI3K Delta Syndrome (APDS) is a primary immunodeficiency disease caused by
activating mutations in either the leukocyte-restricted p110δ catalytic (PIK3CD) subunit or …

Highlights•APDS is caused by activating mutations in PIK3CD or PIK3R1 encoding PI3Kδ
subunits.•Recurrent infection, lymphoproliferation, and immunopathology occur in …

Activated Phosphoinositide 3-kinase δ syndrome (APDS) is a newly recognised primary
immunodeficiency disease. It has currently been a hot topic of clinical research and new …

Background Autosomal dominant gain‐of‐function mutations in PIK 3R1 encoding for the
regulatory subunit (p85α, p55α, and p50α) of Class IA phosphoinositide 3‐kinase (PI 3K) …

Activated phosphoinositide 3-kinase delta syndrome (APDS), caused by mutations in PI3Kδ
catalytic p110δ (PIK3CD) or regulatory p85α (PIK3R1) subunits, is a primary …

Pathogenic gain-of-function mutations in the gene encoding phosphoinositide 3-kinase
delta (PI3Kδ) cause activated PI3Kδ syndrome (APDS), a disease characterized by humoral …