Low level prenatal exposure to methylmercury disrupts neuronal migration in the developing rat cerebral cortex

BQ Guo, CH Yan, SZ Cai, XB Yuan, XM Shen - Toxicology, 2013 - Elsevier
We determined the effects of low-level prenatal MeHg exposure on neuronal migration in the
developing rat cerebral cortex using in utero electroporation. We used offspring rats born to …

Neuronal migration disturbance and consequent cytoarchitecture in the cerebral cortex following transplacental administration of methylmercury

A Kakita, C Inenaga, M Sakamoto, H Takahashi - Acta neuropathologica, 2002 - Springer
To understand the effects of methylmercury (MeHg) on neuronal migration in the developing
cerebral cortex, we performed double administrations of MeHg and 5-bromo-2-deoxyuridine …

Methylmercury distribution in the pregnant rat and embryo during early midbrain organogenesis

TA Lewandowski, CH Pierce, SD Pingree, S Hong… - …, 2002 - Wiley Online Library
Background The period of neurogenesis represents a window of susceptibility for in utero
methylmercury (MeHg) exposure. This study examined the toxicokinetics of potentially …

Disruption of postnatal progenitor migration and consequent abnormal pattern of glial distribution in the cerebrum following administration of methylmercury

A Kakita, C Inenaga, M Sakamoto… - … of Neuropathology & …, 2003 - academic.oup.com
Transplacental administration of methylmercury (MeHg) induces disruption of neuronal
migration in the developing cerebral cortex. However, the effects of MeHg on glial progenitor …

Effects of low level of methylmercury on proliferation of cortical progenitor cells

M Xu, C Yan, Y Tian, X Yuan, X Shen - Brain research, 2010 - Elsevier
Methylmercury (MeHg) is a potent environmental neurotoxin that shows toxicity to
developing central nervous system (CNS), causing brain damage in children even at low …

Mercury distribution in neonatal rat brain after intrauterine methylmercury exposure

G Hu, M Jin, X Lin, C Guo, L Zhang, Z Sun - Environmental Toxicology and …, 2010 - Elsevier
Methylmercuric chloride (MMC) was orally administered to pregnant Wistar rats from
gestational day 6 (G6) for 5 consecutive days. After delivery, the neonatal rats were …

Sub-micromolar methylmercury exposure promotes premature differentiation of murine embryonic neural precursor at the expense of their proliferation

X Yuan, J Wang, HM Chan - Toxics, 2018 - mdpi.com
Methylmercury (MeHg) is a ubiquitous environmental pollutant that is known to be
neurotoxic, particularly during fetal development. However, the mechanisms responsible for …

Dose-dependent effects of methylmercury administered during neonatal brain spurt in rats

M Sakamoto, A Kakita, RB de Oliveira, HS Pan… - Developmental brain …, 2004 - Elsevier
Rapid brain growth occurs primarily during the third trimester in humans, whereas in rats it
occurs after parturition. Therefore, we hypothesized that the effects of methylmercury (MeHg) …

Continuous exposure to low concentrations of methylmercury impairs cerebellar granule cell migration in organotypic slice culture

JD Mancini, DM Autio, WD Atchison - Neurotoxicology, 2009 - Elsevier
Chronic, low-level perinatal exposure to methylmercury (MeHg) is associated with
neurological and motor deficits that appear to result from cerebellar dysfunction …

[HTML][HTML] Exploring the molecular mechanisms underlie the endoplasmic reticulum stress-mediated methylmercury-induced neuronal developmental damage

J Pan, X Li, H Liu, C Wang, S Xu, B Xu, Y Deng… - Ecotoxicology and …, 2022 - Elsevier
Methylmercury (MeHg) is a ubiquitous environmental pollutant, which can cross the placenta
and blood brain barrier, thus affecting fetal growth and development. Although previous …