[HTML][HTML] Indole-based small molecules as potential therapeutic agents for the treatment of fibrosis
R Qin, Q Zhao, B Han, HP Zhu, C Peng… - Frontiers in …, 2022 - frontiersin.org
Indole alkaloids are widely distributed in nature and have been particularly studied because
of their diverse biological activities, such as anti-inflammatory, anti-tumor, anti-bacterial, and …
of their diverse biological activities, such as anti-inflammatory, anti-tumor, anti-bacterial, and …
Natural products as a source for antifibrosis therapy
DQ Chen, YL Feng, G Cao, YY Zhao - Trends in pharmacological sciences, 2018 - cell.com
Although fibrosis is a final pathological feature of many chronic diseases, few interventions
are available that specifically target the pathogenesis of fibrosis. Natural products are …
are available that specifically target the pathogenesis of fibrosis. Natural products are …
Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view
N Chadha, O Silakari - European Journal of Medicinal Chemistry, 2017 - Elsevier
Indoles constitute extensively explored heterocyclic ring systems with wide range of
applications in pathophysiological conditions that is, cancer, microbial and viral infections …
applications in pathophysiological conditions that is, cancer, microbial and viral infections …
Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives
A Kumari, RK Singh - Bioorganic chemistry, 2019 - Elsevier
Indole is a versatile pharmacophore, a privileged scaffold and an outstanding heterocyclic
compound with wide ranges of pharmacological activities due to different mechanisms of …
compound with wide ranges of pharmacological activities due to different mechanisms of …
Medicinal perspective of indole derivatives: recent developments and structure-activity relationship studies
Heterocyclic compounds play a significant role in various biological processes of the human
body and many of them are in clinical use due to their diverse, chemical and biological …
body and many of them are in clinical use due to their diverse, chemical and biological …
[HTML][HTML] Plant-based indole alkaloids: A comprehensive overview from a pharmacological perspective
F Omar, AM Tareq, AM Alqahtani, K Dhama… - Molecules, 2021 - mdpi.com
Plant-based indole alkaloids are very rich in pharmacological activities, and the indole
nucleus is considered to contribute greatly to these activities. This review's fundamental …
nucleus is considered to contribute greatly to these activities. This review's fundamental …
Recent progress in biological activities of indole and indole alkaloids
The indole scaffold is found in a wide range of bioactive heterocycles and natural products.
Moreover, the indole moiety is considered as the active principle in several alkaloids such …
Moreover, the indole moiety is considered as the active principle in several alkaloids such …
Recent progress of bioactivities, mechanisms of action, total synthesis, structural modifications and structure-activity relationships of indole derivatives: a review
T Li, H Xu - Mini Reviews in Medicinal Chemistry, 2022 - ingentaconnect.com
Indole (2, 3-benzopyrrole) containing a pyrrolyl ring possesses the characteristic of electron-
rich aromatic compounds. Indole occurs in the oil of jasmine and cloves and coal tar …
rich aromatic compounds. Indole occurs in the oil of jasmine and cloves and coal tar …
[HTML][HTML] A brief review of the biological potential of indole derivatives
S Kumar, Ritika - Future Journal of Pharmaceutical Sciences, 2020 - Springer
Background Various bioactive aromatic compounds containing the indole nucleus showed
clinical and biological applications. Indole scaffold has been found in many of the important …
clinical and biological applications. Indole scaffold has been found in many of the important …
Harnessing the chemistry of the indole heterocycle to drive discoveries in biology and medicine
VM Norwood IV, RW Huigens III - ChemBioChem, 2019 - Wiley Online Library
Indole‐containing compounds demonstrate an array of biological activities relevant to
numerous human diseases. The biological activities of diverse indole‐based agents are …
numerous human diseases. The biological activities of diverse indole‐based agents are …
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