High rate of discontinuation during long-acting injectable antipsychotic treatment in patients with psychotic disorders

AM Auxilia, M Buoli, A Caldiroli, GS Carnevali… - Biomedicines, 2023 - mdpi.com
Treatment discontinuation is a major challenge in routine clinical settings. Despite poor
adherence to antipsychotic medication, long acting injectable (LAI) formulations are an …

Comparing long-acting antipsychotic discontinuation rates under ordinary clinical circumstances: a survival analysis from an observational, pragmatic study

F Bertolini, G Ostuzzi, M Pievani, A Aguglia, F Bartoli… - CNS drugs, 2021 - Springer
Background Recent guidelines suggested a wider use of long-acting injectable
antipsychotics (LAI) than previously, but naturalistic data on the consequences of LAI use in …

Discontinuation rates during long‐term, second‐generation antipsychotic long‐acting injection treatment: A systematic review

S Gentile - Psychiatry and Clinical Neurosciences, 2019 - Wiley Online Library
Aim The aim of this review was to analyze the discontinuation rates during long‐term
treatment with second‐generation antipsychotic long‐acting injection (SGA‐LAI) in adults …

Identifying patients and clinical scenarios for use of long-acting injectable antipsychotics–expert consensus survey part 1

M Sajatovic, R Ross, SN Legacy… - Neuropsychiatric …, 2018 - Taylor & Francis
Objective To assess expert consensus on barriers and facilitators for long-acting injectable
antipsychotic (LAI) use and provide clinical recommendations on issues where clinical …

Switching to long-acting injectable antipsychotics: pharmacological considerations and practical approaches

M Højlund, CU Correll - Expert Opinion on Pharmacotherapy, 2023 - Taylor & Francis
Introduction Long-acting injectable antipsychotics (LAIs) are an effective, but potentially
underutilized treatment option in schizophrenia and other severe mental illnesses …

Safety and tolerability of long-acting injectable versus oral antipsychotics: a meta-analysis of randomized controlled studies comparing the same antipsychotics

F Misawa, T Kishimoto, K Hagi, JM Kane… - Schizophrenia …, 2016 - Elsevier
Objective We aimed to assess whether long-acting injectable antipsychotics (LAIs), which
are initiated in a loading strategy or overlapping with oral antipsychotics (OAPs) and which …

Time to treatment discontinuation in German patients with schizophrenia: long-acting injectables versus oral antipsychotics

J Mahlich, K Olbrich, A Wilk, A Wimmer… - Clinical drug …, 2021 - Springer
Abstract Background and Objective Long-acting injectable antipsychotics (LAIs) are
associated with better treatment adherence and persistence than oral antipsychotics (OAPs) …

Real-world effectiveness of long-acting injectable antipsychotic treatments in a nationwide cohort of 12,373 patients with schizophrenia-spectrum disorders

L Boyer, B Falissard, P Nuss, C Collin, S Duret… - Molecular …, 2023 - nature.com
This mirror-image study aimed to evaluate the real-life effectiveness of long-acting injectable
antipsychotics (LAI) in schizophrenia. Patients with schizophrenia initiating LAIs January …

Real-world utilization patterns of long-acting injectable antipsychotics in Canada: A retrospective study

O Agid, G Remington, C Fung… - The Canadian …, 2022 - journals.sagepub.com
Objective: The objective of this study was to analyze the real-world prevalence of long-acting
injectable (LAI) antipsychotic use and determine when LAIs are being used in sequencing of …

Does formulation matter? A systematic review and meta-analysis of oral versus long-acting antipsychotic studies

G Ostuzzi, I Bighelli, R So, TA Furukawa… - Schizophrenia research, 2017 - Elsevier
Recently, many authors highlighted the potential advantages of a broader prescription of
long-acting injectable antipsychotics (LAIs) based on various assumptions, including …