Normally-innocuous low-intensity tactile stimuli applied to inflamed tissue induce a
progressive decrease in the mechanical flexion withdrawal threshold, the phenomenon of …

The innervation of the temporomandibular joint (TMJ) has attracted particular interest
because of the close association with complex mandibular movement. Although the …

The aim of this study was to test the hypothesis that temporomandibular joint (TMJ)
inflammation alters the excitability of trigeminal root ganglion (TRG) neurons innervating the …

Substance P is known to exert various pro-inflammatory effects that are mediated by
neurokinin-1 (NK-1) receptor in peripheral tissues. This study examined the effect of the NK …

Purpose: In an attempt to better understand the time course of inflammatory mediator
production or release in inflammatory joint disease, a rabbit model of acute …

Background Inflammation of the temporomandibular joint (TMJ) induced by rheumatoid
arthritis (RA) have resulted in persistent pain and caused distress to many patients …

After peripheral nerve damage macrophages infiltrate the dorsal root ganglia (DRG) in
which cell bodies of lesioned neurons are located. However, infiltration of macrophages into …

Objective Elevated levels of tumor necrosis factor-alpha (TNF-α) in the capsule of the
temporomandibular joint (TMJ) are implicated in the underlying pathology of …

Background The purpose of the present study is to evaluate the mechanisms underlying
tongue-referred pain associated with tooth pulp inflammation. Method Using mechanical …

Three types of tachykinin receptors, namely NK1, NK2 and NK3, are known to preferentially
interact with substance P (SP), neurokinin A (NKA) and neurokinin B (NKB), respectively …