Aims: To investigate nociceptive behavior and the immunoreactivity of microglia and
phosphorylated-p38 (p-p38) mitogen-activated protein kinase (MAPK) following …

Using specific antisera for IL-1β and IL-8, as well as cyclooxygenase inhibitors and
propranolol, we have demonstrated that these cytokines are responsible for the …

Purpose Although mechanical overloading of the temporomandibular joint (TMJ) is
implicated in TMJ osteoarthritis (OA) and orofacial pain, most experimental models of TMJ …

Chronic musculoskeletal pain is a major clinical problem and there is a general lack of
animal models to study this condition. Carrageenan is commonly used to produce short …

This study investigated the role of neurokinin 1 receptors (NK1R) in inflammatory cutaneous
orofacial pain. The effects of subcutaneous and intracisternal administration of the NK1R …

The aim of this study was to investigate the role of P2X3, P2X2/3 and P2X7 receptors in the
development of TMJ hyperalgesia induced by carrageenan. We also investigated the …

Background The existence of referred pain and ectopic paresthesia caused by tooth pulp
inflammation may make definitive diagnosis difficult and cause misdiagnosis or …

Objectives Tropomyosin receptor kinase A (TrkA) mediates nociceptor sensitisation by nerve
growth factor (NGF), but it is unknown whether selective TrkA inhibition will be an effective …

Background Patients with temporomandibular joint disorders (TMD), reactive arthritis and
rheumatoid arthritis often have combined etiology of hereditary and microenvironmental …

We assessed whether intrathecal administration of the uncompetitive and competitive NMDA
receptor antagonists ketamine and (±) CPP, respectively, could produce differential …