Background Patients with temporomandibular joint disorders (TMD), reactive arthritis and
rheumatoid arthritis often have combined etiology of hereditary and microenvironmental …

Temporomandibular joint (TMJ) disorder caused by occlusal trauma is one of the most
controversial topics in dentistry. Experimental traumatic occlusion (ETO) induced by metal …

Objectives Tropomyosin receptor kinase A (TrkA) mediates nociceptor sensitisation by nerve
growth factor (NGF), but it is unknown whether selective TrkA inhibition will be an effective …

Background The existence of referred pain and ectopic paresthesia caused by tooth pulp
inflammation may make definitive diagnosis difficult and cause misdiagnosis or …

Background The proinflammatory cytokine interleukin-1β (IL-1β) drives pain by inducing the
expression of inflammatory mediators; however, its ability to regulate sodium channel 1.7 …

Background Inflammation in the orofacial region results in pain and is associated with many
pathological states, including migraine, neuralgias and temporomandibular disorder …

The aim of the present study was to clarify the involvement of protein kinase Cγ (PKCγ) in
the facial neuropathic pain following infraorbital nerve injury. We analyzed the change in …

Aims: To develop a rat model of temporomandibular joint (TMJ) pain and to characterize in it
the development and temporal response of behavioral hypersensitivity as well as to …

Previous studies have shown that tumor necrosis factor alpha (TNFα) is significantly
increased in complete Freund's adjuvant (CFA)-treated temporomandibular joint (TMJ) …

The pathophysiology of chronic inflammatory pain remains poorly understood. In this
context, we developed an experimental model in which successive daily injection of …