Immunotherapy of sepsis

T Van Der Poll - The Lancet infectious diseases, 2001 - thelancet.com
Sepsis is a clinical syndrome that results from a systemic host response to an infection. The
outcome of sepsis is poor, and mortality rates are as high as 30–40%. Sepsis is associated …

Immunotherapy: a promising approach to reverse sepsis-induced immunosuppression

NK Patil, JK Bohannon, ER Sherwood - Pharmacological Research, 2016 - Elsevier
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
responses to infection (Third International Consensus definition for Sepsis and septic …

[HTML][HTML] Immunotherapy in sepsis-brake or accelerate?

F Steinhagen, SV Schmidt, JC Schewe… - Pharmacology & …, 2020 - Elsevier
Sepsis, a life threating syndrome characterized by organ failure after infection, is the most
common cause of death in hospitalized patients. The treatment of sepsis is generally …

The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer?

JS Boomer, JM Green, RS Hotchkiss - Virulence, 2014 - Taylor & Francis
Sepsis remains the leading cause of death in most intensive care units. Advances in
understanding the immune response to sepsis provide the opportunity to develop more …

Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. Time for a paradigm change?

J Leentjens, M Kox, JG van der Hoeven… - American journal of …, 2013 - atsjournals.org
Sepsis is the leading cause of death in the intensive care unit and ranks in the top 10 causes
of death in general worldwide. Proinflammatory mediators are related to symptoms observed …

[HTML][HTML] Immunotherapy for sepsis: a new approach against an ancient foe

RS Hotchkiss, SM Opal - The New England journal of medicine, 2010 - ncbi.nlm.nih.gov
Septic shock has traditionally been viewed as an excessive systemic inflammatory reaction
to invasive microbial pathogens, yet efforts to improve outcome in septic patients with …

Immunosuppression in sepsis

K Lyn-Kew, TJ Standiford - Current pharmaceutical design, 2008 - ingentaconnect.com
The often fatal sepsis syndrome is characterized by the systemic release of inflammatory
mediators, which is regulated and counterbalanced by the coordinated expression of anti …

Targeting the host response in sepsis: current approaches and future evidence

C Bode, S Weis, A Sauer, P Wendel-Garcia, S David - Critical Care, 2023 - Springer
Sepsis, a dysregulated host response to infection characterized by organ failure, is one of
the leading causes of death worldwide. Disbalances of the immune response play an …

Immunological therapy of sepsis: experimental therapies

P Arndt, E Abraham - Intensive care medicine, 2001 - search.proquest.com
An excessive inflammatory response accompanies the initial stages of severe infection and
appears to contribute to associated organ system failure and death [1, 2, 3]. A number of …

Immune dysregulation in sepsis: experiences, lessons and perspectives

M Cao, G Wang, J Xie - Cell Death Discovery, 2023 - nature.com
Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
responses to infection. Not only does sepsis pose a serious hazard to human health, but it …