Neuronal network excitability in Alzheimer's disease: the puzzle of similar versus divergent roles of amyloid β and tau

SF Kazim, JH Seo, R Bianchi, CS Larson, A Sharma… - Eneuro, 2021 - eneuro.org
Alzheimer's disease (AD) is the most frequent neurodegenerative disorder that commonly
causes dementia in the elderly. Recent evidence indicates that network abnormalities …

Synaptic depression and aberrant excitatory network activity in Alzheimer's disease: two faces of the same coin?

JJ Palop, L Mucke - Neuromolecular medicine, 2010 - Springer
Neurodegenerative diseases, including Alzheimer's disease (AD), target specific and
functionally connected neuronal networks, raising the possibility that neurodegeneration …

Circadian and brain state modulation of network hyperexcitability in Alzheimer's disease

R Brown, AD Lam, A Gonzalez-Sulser, A Ying, M Jones… - Eneuro, 2018 - eneuro.org
Network hyperexcitability is a feature of Alzheimer'disease (AD) as well as numerous
transgenic mouse models of AD. While hyperexcitability in AD patients and AD animal …

Network excitability dysfunction in Alzheimer's disease: insights from in vitro and in vivo models

S Ferrao Santos, N Pierrot, JN Octave - Reviews in the …, 2010 - degruyter.com
Recent reports have drawn attention to dysfunctions of intrinsic neuronal excitability and
network activity in Alzheimer disease (AD). Here we review the possible causes of these …

Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer's disease

KG Ranasinghe, P Verma, C Cai, X Xie, K Kudo, X Gao… - Elife, 2022 - elifesciences.org
Background: Neuronal-and circuit-level abnormalities of excitation and inhibition are shown
to be associated with tau and amyloid-beta (Aβ) in preclinical models of Alzheimer's disease …

[HTML][HTML] Neuronal hyperexcitability in Alzheimer's disease: what are the drivers behind this aberrant phenotype?

H Targa Dias Anastacio, N Matosin, L Ooi - Translational psychiatry, 2022 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to loss of
cognitive abilities and ultimately, death. With no cure available, limited treatments mostly …

Neurophysiological signatures in Alzheimer's disease are distinctly associated with TAU, amyloid-β accumulation, and cognitive decline

KG Ranasinghe, J Cha, L Iaccarino… - Science translational …, 2020 - science.org
Neural synchrony is intricately balanced in the normal resting brain but becomes altered in
Alzheimer's disease (AD). To determine the neurophysiological manifestations associated …

[HTML][HTML] Functional neurophysiological biomarkers of early-stage Alzheimer's disease: A perspective of network hyperexcitability in disease progression

S Tok, A Ahnaou… - Journal of Alzheimer's …, 2022 - content.iospress.com
Network hyperexcitability (NH) has recently been suggested as a potential
neurophysiological indicator of Alzheimer's disease (AD), as new, more accurate biomarkers …

Unsupervised excitation: GABAergic dysfunctions in Alzheimer's disease

EA Giovannetti, M Fuhrmann - Brain research, 2019 - Elsevier
Alzheimer's disease (AD) is characterized by the classical hallmarks of Aβ-deposition and
tau-pathology that are thought to ultimately lead to synapse and neuron loss. Although long …

[HTML][HTML] Hippocampal oscillatory activity in Alzheimer's disease: toward the identification of early biomarkers?

R Goutagny, S Krantic - Aging and disease, 2013 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) develops for a yet unknown period of time and can progress
undiagnosed for years before its first clinical manifestation consisting of characteristic …