Rapid evolution bacteria reveal pathogenic mechanisms and clinical risk

T Sato, K Uemura, K Aoki, S Yamamoto, N Ogasawara… - 2023 - researchsquare.com
Bacteria continually evolve, as postulated in Darwin's theory of evolution 1-3. Previous
studies have evaluated bacterial evolution in retrospect, but this approach is based on only …

Experimental evolution can unravel the complex causes of natural selection in clinical infections

MA Brockhurst - Microbiology, 2015 - microbiologyresearch.org
It is increasingly clear that rapid evolutionary dynamics are an important process in microbial
ecology. Experimental evolution, wherein microbial evolution is observed in real-time, has …

Stepwise evolution of a Klebsiella pneumoniae clone within a host leading to increased multidrug resistance

M Yoshino, M Aihara, Y Gotoh, M Akimoto… - Msphere, 2021 - Am Soc Microbiol
ABSTRACT Five bla CTX-M-14-positive Klebsiella pneumoniae isolates (KpWEA1,
KpWEA2, KpWEA3, KpWEA4-1, and KpWEA4-2) were consecutively obtained from a patient …

[HTML][HTML] Bacterial evolution during human infection: adapt and live or adapt and die

MJ Culyba, D Van Tyne - PLoS Pathogens, 2021 - journals.plos.org
Microbes are constantly evolving. Laboratory studies of bacterial evolution increase our
understanding of evolutionary dynamics, identify adaptive changes, and answer important …

Dissecting the clinical significance of evolving pathogen diversity

C Wagner - 2024 - digital.lib.washington.edu
A diversity of pathogens threaten human health. These pathogens include eukaryotes,
prokaryotes, and viruses, together encompassing significant variation in their biology. Some …

[HTML][HTML] Our unique microbial identity

JA Gilbert - Genome biology, 2015 - Springer
Our unique microbial identity | Genome Biology Skip to main content SpringerLink Account Menu
Find a journal Publish with us Track your research Search Cart 1.Home 2.Genome Biology …

[HTML][HTML] Bacterial survival: evolve and adapt or perish

C Chaguza - Nature Reviews Microbiology, 2020 - nature.com
Bacterial survival: evolve and adapt or perish | Nature Reviews Microbiology Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Within-host evolution of bacterial pathogens during persistent infection of humans

A Grote, AM Earl - Current Opinion in Microbiology, 2022 - Elsevier
Highlights•Some persistent infections are linked to drug resistance and adverse outcomes
such as cancer.•Longitudinal human-infection studies offer access to early and late infection …

Genome-wide identification of Klebsiella pneumoniae fitness genes during lung infection

MA Bachman, P Breen, V Deornellas, Q Mu, L Zhao… - MBio, 2015 - Am Soc Microbiol
Klebsiella pneumoniae is an urgent public health threat because of resistance to
carbapenems, antibiotics of last resort against Gram-negative bacterial infections. Despite …

Convergent within-host evolution alters key virulence factors in a Klebsiella pneumoniae clone during a large hospital outbreak

G Zaborskytė, K Hjort, B Lytsy, L Sandegren - bioRxiv, 2024 - biorxiv.org
Bacterial pathogens adapt to host niches because of within-host selective pressures, and
this evolutionary process provides valuable insights into host-pathogen interactions …