Many bacteria, including numerous human pathogens, synthesize small molecules known
as siderophores to scavenge iron. Enterobactin, a siderophore produced by enteric bacteria …

Numerous bacteria cope with the scarcity of iron in their microenvironment by synthesizing
small iron-scavenging molecules known as siderophores. Mammals have evolved …

The siderophore enterobactin (Ent) is produced by enteric bacteria to mediate iron uptake.
Ent scavenges iron and is taken up by the bacteria as the highly stable ferric complex [FeIII …

Enteric Gram-negative bacteria, including Escherichia coli, biosynthesize and deploy the
triscatecholate siderophore enterobactin (Ent) in the vertebrate host to acquire iron, an …

Bacteria have aggressive acquisition processes for iron, an essential nutrient. Siderophores
are small iron chelators that facilitate cellular iron transport. The siderophore enterobactin is …

Bacteria use tight-binding, ferric-specific chelators called siderophores to acquire iron from
the environment and from the host during infection; animals use proteins such as transferrin …

Siderocalin, a member of the lipocalin family of binding proteins, is found in neutrophil
granules, uterine secretions, and at markedly elevated levels in serum and synovium during …

Bacterial pathogens use siderophores to obtain iron from the host in order to survive and
grow. The host defends against siderophore-mediated iron acquisition by producing …

Siderophores are low molecular weight, high affinity iron chelating molecules that are
essential virulence factors in many Gram-negative bacterial pathogens. Whereas the …

New antibiotics are required to treat bacterial infections and counteract the emergence of
antibiotic resistance. Pathogen-specific antibiotics have several advantages over broad …