Enteroviruses, type 1 diabetes and hygiene: a complex relationship

S Tracy, KM Drescher, JD Jackson… - Reviews in medical …, 2010 - Wiley Online Library
Abstract Type 1 diabetes (T1D) is an autoimmune disease in which the immune system
mounts an attack on the host's insulin‐producing β cells. Because most cases of T1D cannot …

Enterovirus persistence as a mechanism in the pathogenesis of type 1 diabetes

EK Alidjinou, F Sane, I Engelmann, V Geenen… - Discovery …, 2014 - orbi.uliege.be
Beyond acute clinical conditions, the role of enteroviruses (EVs) in chronic human diseases
has been described. Although they are considered as highly cytolytic viruses, EVs can …

Enterovirus variants in the serum of children at the onset of type 1 diabetes mellitus

C Nairn, DN Galbraith, KW Taylor… - Diabetic …, 1999 - Wiley Online Library
Aims This study was designed to assess further the possible links between enterovirus
infection and Type 1 diabetes mellitus (DM). Methods Sera from 110 children in the age …

[HTML][HTML] Viruses and type 1 diabetes: from enteroviruses to the virome

SR Isaacs, DB Foskett, AJ Maxwell, EJ Ward… - Microorganisms, 2021 - mdpi.com
For over a century, viruses have left a long trail of evidence implicating them as frequent
suspects in the development of type 1 diabetes. Through vigorous interrogation of viral …

Enteroviruses and type 1 diabetes: towards a better understanding of the relationship

H Jaïdane, P Sauter, F Sane, A Goffard… - Reviews in medical …, 2010 - Wiley Online Library
Environmental factors, especially viruses, are involved in the initiation or the acceleration of
type 1 diabetes (T1D) pathogenesis. Epidemiological data strongly suggest that …

Prospective study of enteroviral infections and development of beta-cell autoimmunity: Diabetes Autoimmunity Study in the Young (DAISY)

PM Graves, HA Rotbart, WA Nix, MA Pallansch… - Diabetes research and …, 2003 - Elsevier
Objective: To determine whether there is association between infection with enteroviruses
and beta-cell autoimmunity in children at elevated risk of developing type 1 diabetes …

Enterovirus infections and insulin dependent diabetes mellitus—evidence for causality

H Hyöty, M Hiltunen, M Lönnrot - Clinical and diagnostic virology, 1998 - Elsevier
Background: Insulin-dependent diabetes mellitus (IDDM) has a long subclinical period
characterised by gradually progressing autoimmune damage of insulin producing beta-cells …

[HTML][HTML] High titres of IgA antibodies to enterovirus in fulminant type-1 diabetes

A Imagawa, T Hanafusa, H Makino, JI Miyagawa… - Diabetologia, 2005 - Springer
Aims/hypothesis We have recently proposed that fulminant type-1 diabetes is a novel
subtype of type-1 diabetes with abrupt onset of insulin-deficient hyperglycaemia without islet …

[PDF][PDF] Enterovirus infection of human β-cells activates dendritic cells and triggers innate antiviral responses: are enteroviruses convicted now?

U Christen - Diabetes, 2010 - researchgate.net
Despite a large number of epidemiologic associ-ations, clinical studies, and animal models,
a direct involvement of pathogens in the etiology of human type 1 diabetes is still a matter of …

Enterovirus RNA in serum is a risk factor for beta‐cell autoimmunity and clinical type 1 diabetes: A prospective study

M Lönnrot, K Salminen, M Knip, K Savola… - Journal of medical …, 2000 - Wiley Online Library
Recent prospective studies have documented serologically an increased frequency of
enterovirus infections in prediabetic children, indicating that these infections may initiate and …