New therapeutic strategies for malignant pleural mesothelioma

MA Bonelli, C Fumarola, S La Monica… - Biochemical pharmacology, 2017 - Elsevier
Malignant pleural mesothelioma (MPM) is a rare and aggressive malignant disease affecting
the mesothelium, commonly associated to asbestos exposure. Therapeutic actions are …

Ratio of intratumoral macrophage phenotypes is a prognostic factor in epithelioid malignant pleural mesothelioma

R Cornelissen, LA Lievense, AP Maat, RW Hendriks… - PloS one, 2014 - journals.plos.org
Hypothesis The tumor micro-environment and especially the different macrophage
phenotypes appear to be of great influence on the behavior of multiple tumor types. M1 …

Updates in the diagnosis and treatment of malignant pleural mesothelioma

D Katzman, DH Sterman - Current opinion in pulmonary medicine, 2018 - journals.lww.com
MPM remains difficult to treat and has an overall poor prognosis despite current
multimodality treatment. Thoracoscopy with multiple pleural biopsies can provide adequate …

New perspectives on diagnosis and therapy of malignant pleural mesothelioma

M Rossini, P Rizzo, I Bononi, A Clementz… - Frontiers in …, 2018 - frontiersin.org
Malignant pleural mesothelioma (MPM) is a rare, but severe form of cancer, with an
incidence that varies significantly within and among different countries around the world. It …

Novel therapeutic targets and immune dysfunction in malignant pleural mesothelioma

M Lapidot, SV Saladi, R Salgia, M Sattler - Frontiers in Pharmacology, 2022 - frontiersin.org
Advances in the treatment of malignant pleural mesothelioma (MPM) have been
disappointing, despite the apparent need for new therapeutic options for this rare and …

[HTML][HTML] Multimodality treatment of malignant pleural mesothelioma

L Berzenji, P Van Schil - F1000Research, 2018 - ncbi.nlm.nih.gov
Malignant pleural mesothelioma (MPM) is a rare disease of the pleura and is largely related
to asbestos exposure. Despite recent advancements in technologies and a greater …

Emerging avenues in immunotherapy for the management of malignant pleural mesothelioma

SG Gray - BMC Pulmonary Medicine, 2021 - Springer
Background The role of immunotherapy in cancer is now well-established, and therapeutic
options such as checkpoint inhibitors are increasingly being approved in many cancers such …

[HTML][HTML] Target therapy: new drugs or new combinations of drugs in malignant pleural mesothelioma

PA Zucali - Journal of thoracic disease, 2018 - ncbi.nlm.nih.gov
Malignant pleural mesothelioma (MPM) is a disease with a poor prognosis due to its
aggressive nature. The management of patients with MPM is controversial. Considering that …

[HTML][HTML] Pleural effusion of patients with malignant mesothelioma induces macrophage-mediated T cell suppression

LA Lievense, R Cornelissen, K Bezemer… - Journal of Thoracic …, 2016 - Elsevier
Introduction Clinical studies have demonstrated beneficial effects of immunotherapy in
malignant pleural mesothelioma. The pleural cavity seems an attractive compartment to …

ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma

A Scherpereel, I Opitz, T Berghmans… - European respiratory …, 2020 - Eur Respiratory Soc
The European Respiratory Society (ERS)/European Society of Thoracic Surgeons
(ESTS)/European Association for Cardio-Thoracic Surgery (EACTS)/European Society for …