Sepsis is a clinical syndrome that results from a systemic response of the host to an
infection. Activation of inflammatory pathways, including the cytokine network, is considered …

Several clinical trials have attempted to treat sepsis by blocking certain aspects of the
inflammatory response. Tumor necrosis factor and interleukin 1 have been specific targets …

Sepsis is currently listed as the 13th leading cause of death in the United States, and it is on
the rise. Factors thought to account for this recent increase include an aging population …

Publisher Summary This chapter reviews the role of cytokines in the pathogenesis of sepsis.
The various models for sepsis are also discussed, including the human models and animal …

Strategies for blocking the systemic effects of cytokines in... : Critical Care Medicine Strategies
for blocking the systemic effects of cytokines in the sepsis syndrome : Critical Care Medicine …

Objectives To review the role of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1
(IL-1) in the proinflammatory cascade, with particular emphasis on the association between …

Sepsis is associated with an exacerbated production of both pro-and anti-inflammatory
cytokines, which are detectable within the bloodstream. Their'half-angel, half-devil'properties …

Background: Sepsis is a deadly immunological disorder and its pathophysiology is still
poorly understood. We aimed to determine if specific pro-inflammatory and anti-inflammatory …

We tested the hypothesis that, during sepsis, the balance of pro-and anti-inflammatory
cytokines is related to severity and survival. Cecal ligation and puncture (CLP) with a large …

The roles of inflammation and coagulation in the pathophysiology of sepsis are described.
Sepsis results when an infectious insult triggers a localized inflammatory reaction that then …