Pancreatic ischemia/reperfusion injury: impact of different preservation temperatures

R Obermaier, O Drognitz, S Benz, UT Hopt, P Pisarski - Pancreas, 2008 - journals.lww.com
Objectives: Pancreatic ischemia/reperfusion injury (IRI) can influence the results after
transplantation. Temperature during ischemia can affect IRI. A temperature of 4 C is …

Characterization and reduction of ischemia/reperfusion injury after experimental pancreas transplantation

H Mayer, J Schmidt, J Tbies, E Ryschich… - Journal of …, 1999 - Springer
Reperfusion injury after pancreas transplantation is a cause of early graft pancreatitis. The
aim of this study was to quantify pancreatic microcirculation after pancreas transplantation in …

Ischemic preconditioning fails to improve microcirculation but increases apoptotic cell death in experimental pancreas transplantation

O Drognitz, X Liu, R Obermaier, H Neeff… - Transplant …, 2004 - Wiley Online Library
Brief periods of warm ischemia and subsequent short reperfusion before either long‐term
cold or warm ischemic insult (ischemic preconditioning, IPC) have proven to ameliorate …

[HTML][HTML] Effects of organ preservation, ischemia time and caspase inhibition on apoptosis and microcirculation in rat pancreas transplantation

O Drognitz, R Obermaier, X Liu, H Neeff… - American Journal of …, 2004 - Elsevier
This study was undertaken to examine the impact of ischemia-reperfusion (I/R) injury on
microcirculation and apoptosis in experimental pancreas transplantation. Pancreatic grafts …

Ischemia/reperfusion-induced pancreatitis in rats: a new model of complete normothermic in situ ischemia of a pancreatic tail-segment

R Obermaier, S Benz, B Kortmann, A Benthues… - Clinical and …, 2001 - Springer
Ischemia/reperfusion injury plays an important role in the development of graft pancreatitis
and thrombosis after pancreas transplantation. Up to now there are few therapeutic options …

Ischemia/reperfusion injury of the pancreas: a new animal model

S Benz, R Schnabel, K Morgenroth, H Weber… - Journal of Surgical …, 1998 - Elsevier
Background. Ischemia/reperfusion is thought to play an important role in the development of
postimplantation pancreatitis after pancreas transplantation and also in the transition of …

Protection of canine pancreatic microvascular endothelium against cold ischemic injury during preservation by the two-layer method

Y Kuroda, H Fujita, S Matsumoto, Y Suzuki, Y Kim… - …, 1997 - journals.lww.com
Background Ischemic injury of the microvascular endothelium during cold preservation
causes a disturbance of vascular microcirculation after reperfusion and results in graft …

A novel technique for heterotopic vascularized pancreas transplantation in mice to assess ischemia reperfusion injury and graft pancreatitis

M Maglione, M Hermann, P Hengster, S Schneeberger… - Surgery, 2007 - Elsevier
BACKGROUND: Although various suture techniques for murine pancreas transplantation
have been described, severe limitations have limited their widespread use. We therefore …

Characterization of Microcirculatory Disturbance in a Novel Model of Pancreatic Ischemia–Reperfusion Using Intravital Fluorescence–Microscopy

R Obermaier, S Benz, E Von Dobschuetz, O Drognitz… - Pancreas, 2002 - journals.lww.com
Aims To develop a novel rodent model of normothermic in situ ischemia of a pancreatic tail-
segment that simulates the clinical situation of pancreas transplantation by flushing the …

Endotoxin preconditioning in pancreatic ischemia/reperfusion injury

R Obermaier, O Drognitz, A Grub, E von Dobschuetz… - Pancreas, 2003 - journals.lww.com
Objectives Prospective organ donors are exposed to various stress types. The effect of
endotoxin pretreatment (ETX) on pancreatic ischemia/reperfusion injury (IRI) is unclear. We …