Trichogin GA IV, isolated from the fungus Trichoderma longibrachiatum, is the prototype of
lipopeptaibols, the sub-class of short-length peptaibiotics exhibiting membrane-modifying …

The lipopeptaibol trichogin GA IV is a natural, non-ribosomally synthesized, antimicrobial
peptide remarkably resistant to the action of hydrolytic enzymes. This feature may be …

Peptaibols are peculiar peptides produced by fungi as weapons against other
microorganisms. Previous studies showed that peptaibols are promising peptide-based …

Peptaibiotics, non-ribosomally synthetized peptides from various ascomycetes, are uniquely
characterized by di-alkylated α-amino acids, a rigid helical conformation, and membrane …

New classes of antibacterial drugs are urgently needed to address the global issue of
antibiotic resistance. In this context, peptaibols are promising membrane-active peptides …

The antibacterial and hemolytic activities of the amphiphilic helical, membrane‐active,
lipopeptaibol trichogin GA IV and its [Leu11‐OMe] analogue were compared to those of the …

To investigate the effect of backbone length and amphiphilicity on the 3D structure,
membrane permeability, and antibacterial properties of trichogins, a subclass of …

The solid‐phase synthesis and full chemical characterization of the medium‐length (14‐
amino acid residues) peptaibol with antibiotic properties of tylopeptin B, originally extracted …

We have synthesized by solution‐phase methods two analogues of the 11‐residue
lipopeptaibol antibiotic trichogin GA IV in which the N‐terminal n‐octanoyl group is replaced …

We prepared by solid‐phase methods, chromatographically purified, and characterized
three analogs of the ten‐amino acid‐residue, membrane‐active, lipopeptaibiotic trichogin …