The resistance to chemotherapy of cancer cells is mediated by the overexpression of P-
glycoprotein, as an ATP-dependent membrane efflux pump. Two families of compounds …

The ability of 11 chalcones with 3, 4, 5-trimethoxy substitution on ring A to inhibit the
transport activity of P-glycoprotein was studied. Flow cytometry was applied in multidrug …

The multidrug resistance (MDR) proteins are member of the ATP-binding cassette
superfamily and are present in a majority of human tumors. Their activity is a crucial factor …

Multidrug resistance (MDR) mediated by overexpression of MDR1 P-glycoprotein (P-gp) is
one of the best characterized transporter-mediated barriers to successful chemotherapy in …

Multidrug resistance (MDR) mediated by the over expression of drug efflux protein P-
glycoprotein (P-gp) is one of the major impediments to successful treatment of cancer. P-gp …

Background: Ineffectiveness of anticancer drugs is frequently observed in cancer
chemotherapy. The resistance of tumor cells to various cytotoxic drugs is defined as …

Multidrug resistance (MDR) in cancer cells is often associated with overexpression of ATP-
binding cassette (ABC) transporters, including P-glycoprotein (P-gp/ABCB1), multidrug …

Multidrug resistance (MDR) is one of conventional cancer chemotherapy's limitations. Our
group previously synthesized a series of quinoline-based compounds in an attempt to …

Numerous compounds have been identified that sensitize multidrug-resistant cells to
chemotherapeutic drugs in experimental systems. The mechanism of activity of these …

The ability of 41 1, 4-diphenyl-1, 4-dihydropyridine derivatives to inhibit the transport activity
of P-glycoprotein were studied by flow cytometry in a multidrug-resistant human colon …