BACKGROUND We recently developed a novel, noninvasive method for sampling
nonvolatile material from the distal airways. The method is based on the collection of …

Purpose Ultrafine particles (UFP) are toxic due to their small size and penetration into
deeper lung compartments. We aimed to evaluate the exhaled breath condensate (EBC) …

Of the three major particulate matter (PM) size fractions (ultrafine, fine, and coarse), coarse
PM (PM2. 5-10) has been the least examined in terms of its health effects on susceptible …

Respiratory tract lining fluid (RTLF) is an important component of the lung epithelial barrier.
Pathological changes in RTLF may cause increased permeability of the epithelial barrier …

Asthma is a complex disease that alters both breathing patterns and airway morphology.
Lack of experimental data or model simulations utilizing realistic in vivo breathing conditions …

Monodisperse aerosol particles can be used to assess noninvasively intrapulmonary
airspace dimensions. Since emphysematic changes in the peripheral lung are difficult to …

Background: Small-particle inhaled corticosteroids (ICS) provide a higher small airway
deposition than large-particle ICS. However, we are still not able to identify asthma patients …

Background Surfactant phospholipid (PL) composition plays an important role in lung
diseases. We compared the PL composition of non-invasively collected exhaled breath …

To cite this article: Contoli M, Bousquet J, Fabbri LM, Magnussen H, Rabe KF, Siafakas NM,
Hamid Q, Kraft M. The small airways and distal lung compartment in asthma and COPD: a …

Rationale: Optimization of regional particle dosimetry in asthmatic subjects may improve
tissue dose concentrations while reducing adverse side effects. Recently, we developed a …