Regarding safety concerns, nonviral gene delivery vehicles that have the required efficiency
and safety for use in human gene therapy are being widely investigated. The aim of this …

Purpose Thiolated chitosan appears to possess enhanced mucoadhesiveness and cell
penetration properties, however, its potential in gene-drug delivery remains unknown …

Currently, the major drawback of gene therapy is the gene transfection rate. The two main
types of vectors that are used in gene therapy are based on viral or non-viral gene delivery …

Among non-viral vectors, chitosan and chitosan derivatives have been developed in vitro
and in vivo for DNA and siRNA delivery systems because of their cationic charge …

Nanoparticles generated by complex coacervation of plasmid DNA (pDNA) and modified
chitosans namely chitosan–thioglycolic acid (TGA) conjugate and chitosan–HIV-1 Tat …

Chitosan can be useful as a nonviral vector for gene delivery. Although there are several
reports to form chitosan-pDNA particles, the optimization and effect on transfection remain …

The present study aimed to investigate in vitro DNA transfection efficiency of three novel
chitosan derivatives: thiolated trimethyl chitosan (TMC-Cys), methylated 4-N, N dimethyl …

Chitosan-DNA nanoparticles were prepared using a complex coacervation process. The
important parameters for the nanoparticle synthesis were investigated, including the …

Conventional gene delivery with viral or lipid carriers-are plagued by disadvantages such as
low transfection efficiency, cytotoxicity and immunogenicity. Numerous techniques are being …

Chitosan is a biodegradable natural polysaccharide that has shown potential for gene
delivery, although the ideal molecular weight (MW) and degree of deacetylation (DDA) for …