PURPOSE: Halofuginone (tempostatin™) is a synthetic derivative of a quinazolinone
alkaloid showing anti-angiogenic, anti-metastatic and anti-proliferative effects in preclinical …

Purpose: Halofuginone (HF) inhibits synthesis of collagen type I and matrix
metalloproteinase-2 and is being considered for clinical evaluation as an antineoplastic …

Abstract Purpose Kahalalide F (KF) is a dehydroaminobutyric acid-containing peptide from
marine origin with activity against several human malignant cell lines. This dose-escalating …

Abstract Purpose: We performed a Phase I and pharmacokinetic study to determine the
maximum tolerated dose of irofulven (6-hydroxymethylacylfulvene; MGI-114, MGI PHARMA …

Halofuginone, a widely used alkaloid coccidiostat, is a potent inhibitor of collagen α1 (I) and
matrix metalloproteinase 2 gene expression. Halofuginone also suppresses extracellular …

We have previously demonstrated that halofuginone, a widely used alkaloid coccidiostat, is
a potent inhibitor of collagen α1 (I) and matrix metalloproteinase 2 gene expression …

Halofuginone has recently been shown to inhibit tumor progression of various types of
cancers. The antitumoral effect was associated with decreased tumor angiogenesis rather …

Purpose: Voreloxin, a novel replication-dependent DNA-damaging agent, intercalates DNA
and inhibits topoisomerase II. Voreloxin induces site-selective DNA double-strand breaks …

Vorinostat (suberoylanilide hydroxamic acid), a potent, oral histone deacetylase inhibitor,
has demonstrated clinical activity in non‐Japanese patients with various hematological and …

Purpose: Receptor tyrosine kinases c-Met and Ron transduce signals regulating cell
migration and matrix invasion. This phase I dose-escalation trial tested golvatinib, a highly …