Abstract PDE4D (Phosphodiesterase 4D) gene encodes a hydrolase of cyclic AMP. PDE4D
genetic variants have been associated with asthma susceptibility. Therefore, this study …

Repository at www. jacionline. org), all of which validated the original findings. Furthermore,
we examined the evidence for association to SNPs within PDE11A in 5 independent …

Asthma, a chronic airway disease with known heritability, affects more than 300 million
people around the world. A genome-wide association (GWA) study of asthma with 359 …

Short-acting b2-adrenergic receptor agonists are commonly used bronchodilators for
symptom relief in asthmatics. The aim of this study was to test whether genetic variants in …

DPP10 for asthma susceptibility and related traits in an adult Han Chinese population of
asthmatics with high IgE levels. Two markers in PHF11 (rs1046295 and rs16659) were …

Background Six asthma candidate genes, ADAM33, NPSR1, PHF11, DPP10, HLA-G, and
CYFIP2, located at different chromosome regions have been positionally cloned following …

Background Recent genome-wide association studies (GWAS) for asthma have been
successful in identifying novel associations which have been well replicated. The aim of this …

Background: Initial studies by positional cloning have identified the genes encoding the
plant homeodomain zinc finger protein 11 (PHF11) and dipeptidyl-peptidase 10 (DPP10) as …

Objective: The programmed death-1 receptor, PD-1, is a negative regulator of T-cell
activation. The PD-1.3 polymorphism of the PD-1 gene (PDCD1) has been previously shown …

ABSTRACT A previous genome‐wide association study in asthma revealed putative
associations that merit further investigation. In this study, the genome‐wide significant …