Systematic review and meta-analysis of the efficacy of appropriate empiric antibiotic therapy for sepsis
Quantifying the benefit of early antibiotic treatment is crucial for decision making and can be
assessed only in observational studies. We performed a systematic review of prospective …
assessed only in observational studies. We performed a systematic review of prospective …
Outcome of immediate versus early antibiotics in severe sepsis and septic shock: a systematic review and meta-analysis
SG Rothrock, DD Cassidy, M Barneck… - Annals of emergency …, 2020 - Elsevier
Study objective Debate exists about the mortality benefit of administering antibiotics within
either 1 or 3 hours of sepsis onset. We performed this meta-analysis to analyze the effect of …
either 1 or 3 hours of sepsis onset. We performed this meta-analysis to analyze the effect of …
Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis
J Garnacho-Montero, JL Garcia-Garmendia… - Critical care …, 2003 - journals.lww.com
Objectives Our primary goal was to evaluate the impact on in-hospital mortality rate of
adequate empirical antibiotic therapy, after controlling for confounding variables, in a cohort …
adequate empirical antibiotic therapy, after controlling for confounding variables, in a cohort …
Empiric combination antibiotic therapy is associated with improved outcome against sepsis due to Gram-negative bacteria: a retrospective analysis
The optimal approach for empirical antibiotic therapy in patients with severe sepsis and
septic shock remains controversial. A retrospective cohort study was conducted in the …
septic shock remains controversial. A retrospective cohort study was conducted in the …
The impact of timing of antibiotics on outcomes in severe sepsis and septic shock: a systematic review and meta-analysis
SA Sterling, WR Miller, J Pryor, MA Puskarich… - Critical care …, 2015 - journals.lww.com
Objectives: We sought to systematically review and meta-analyze the available data on the
association between timing of antibiotic administration and mortality in severe sepsis and …
association between timing of antibiotic administration and mortality in severe sepsis and …
Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program
R Ferrer, I Martin-Loeches, G Phillips… - Critical care …, 2014 - journals.lww.com
Objectives: Compelling evidence has shown that aggressive resuscitation bundles,
adequate source control, appropriate antibiotic therapy, and organ support are cornerstone …
adequate source control, appropriate antibiotic therapy, and organ support are cornerstone …
Does early and appropriate antibiotic administration improve mortality in emergency department patients with severe sepsis or septic shock?
Background Severe sepsis and septic shock remain significant public health concerns.
Appropriate emergency department management includes early recognition, hemodynamic …
Appropriate emergency department management includes early recognition, hemodynamic …
A survival benefit of combination antibiotic therapy for serious infections associated with sepsis and septic shock is contingent only on the risk of death: a meta-analytic …
Objective: To assess whether a potential benefit with combination antibiotic therapy is
restricted to the most critically ill subset of patients, particularly those with septic shock. Data …
restricted to the most critically ill subset of patients, particularly those with septic shock. Data …
Inappropriate antibiotic therapy in Gram-negative sepsis increases hospital length of stay
AF Shorr, ST Micek, EC Welch, JA Doherty… - Critical care …, 2011 - journals.lww.com
Objectives: To describe the impact of initially inappropriate antibiotic therapy on hospital
length of stay in Gram-negative severe sepsis and septic shock. Design: Retrospective …
length of stay in Gram-negative severe sepsis and septic shock. Design: Retrospective …
Antibiotics for sepsis—finding the equilibrium
Sepsis is medicine's last remaining preserve for unrestrainedantibioticprescribing.
TheSurvivingSepsisCampaign guidelines recommend empirical broadspectrum therapy …
TheSurvivingSepsisCampaign guidelines recommend empirical broadspectrum therapy …