Quantifying the benefit of early antibiotic treatment is crucial for decision making and can be
assessed only in observational studies. We performed a systematic review of prospective …

Study objective Debate exists about the mortality benefit of administering antibiotics within
either 1 or 3 hours of sepsis onset. We performed this meta-analysis to analyze the effect of …

Objectives Our primary goal was to evaluate the impact on in-hospital mortality rate of
adequate empirical antibiotic therapy, after controlling for confounding variables, in a cohort …

The optimal approach for empirical antibiotic therapy in patients with severe sepsis and
septic shock remains controversial. A retrospective cohort study was conducted in the …

Objectives: We sought to systematically review and meta-analyze the available data on the
association between timing of antibiotic administration and mortality in severe sepsis and …

Objectives: Compelling evidence has shown that aggressive resuscitation bundles,
adequate source control, appropriate antibiotic therapy, and organ support are cornerstone …

Objective: To assess whether a potential benefit with combination antibiotic therapy is
restricted to the most critically ill subset of patients, particularly those with septic shock. Data …

Background Severe sepsis and septic shock remain significant public health concerns.
Appropriate emergency department management includes early recognition, hemodynamic …

Objectives: To describe the impact of initially inappropriate antibiotic therapy on hospital
length of stay in Gram-negative severe sepsis and septic shock. Design: Retrospective …

Sepsis is medicine's last remaining preserve for unrestrainedantibioticprescribing.
TheSurvivingSepsisCampaign guidelines recommend empirical broadspectrum therapy …