The concept of cancer immunotherapy has gained immense momentum over the recent
years. The advancements in checkpoint blockade have led to a notable progress in treating …

Regulatory T cells (Tregs) are key immunosuppressive cells that promote tumor growth by
hindering the effector immune response. Tregs utilize multiple suppressive mechanisms to …

The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …

Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance and
preventing autoimmunity. However, they also represent a major barrier to effective antitumor …

The immune system mediates powerful effector mechanisms to protect against a diversity of
pathogens and equally as important regulatory functions, to limit collateral damage of …

Immunotherapies have revolutionized the landscape of cancer treatment. Regulatory T cells
(Tregs), as crucial components of the tumor immune environment, has great therapeutic …

With the broad application of cancer immunotherapies such as immune checkpoint inhibitors
in multiple cancer types, the immunological landscape in the tumor microenvironment (TME) …

Immunosuppressive regulatory T cells (Tregs) provide a main mechanism of tumor immune
evasion. Targeting Tregs, especially in the tumor microenvironment (TME), continues to be …

Regulatory T (Treg) cells are required for maintaining self‐tolerance and preventing the
development of autoimmune diseases. However, Treg cells are abundant in tumors and …

Treg play a central role in maintenance of self tolerance and homeostasis through
suppression of self-reactive T cell populations. In addition to that role, Treg also survey …